Morell P, Braun P
J Lipid Res. 1972 May;13(3):293-310.
Interest in sphingolipid metabolism has increased rapidly during the past decade, and many of the steps involved in the biosynthesis and metabolic degradation of sphingolipids are now known. In this review these studies are critically examined. Emphasis has been placed on the in vitro studies with cell-free systems, since these represent the groundwork for further purification and characterization of the enzyme systems involved. Experimental problems specific to this field of study, and the manner in which these may affect interpretation of experimental results, are discussed.
在过去十年中，对鞘脂代谢的研究兴趣迅速增长，目前已知鞘脂生物合成和代谢降解过程中的许多步骤。在这篇综述中，对这些研究进行了批判性审视。重点放在了无细胞系统的体外研究上，因为这些研究是进一步纯化和鉴定相关酶系统的基础。讨论了该研究领域特有的实验问题，以及这些问题可能影响实验结果解释的方式。
