Ginter E, Bobek P, Vargová D
Nutr Metab. 1979;23(3):217-26. doi: 10.1159/000176259.
Ascorbic acid mixed with the diet of guinea pigs achieved substantially higher maximum tissue concentrations of ascorbate than when ascorbic acid was administered orally once a day. A 0.5% w/w of ascorbic acid in the diet ensured a state close to maximal tissue steady-state levels of ascorbate. In guinea pigs fed a diet with a high content of saturated fatty acids or with 0.2% w/w of cholesterol, the highest rate of cholesterol transformation into bile acids and the lowest concentration of total lipids, cholesterol and triglycerides in blood serum and liver were found in the group fed a diet with 0.5% w/w of ascorbic acid as compared to the marginal-deficiency group and the group receiving 0.05% w/w of ascorbic acid in the diet. Maximal tissue steady-state levels of vitamin C are probably optimal for the guinea pigs' health.
与每天口服一次抗坏血酸相比，将抗坏血酸混入豚鼠饮食中可使组织中抗坏血酸盐的最大浓度显著更高。饮食中0.5%（重量/重量）的抗坏血酸可确保接近抗坏血酸盐组织稳态水平的最大值。在喂食高饱和脂肪酸含量或0.2%（重量/重量）胆固醇饮食的豚鼠中，与边缘缺乏组和饮食中摄入0.05%（重量/重量）抗坏血酸的组相比，在喂食0.5%（重量/重量）抗坏血酸饮食的组中发现胆固醇转化为胆汁酸的速率最高，血清和肝脏中总脂质、胆固醇和甘油三酯的浓度最低。维生素C的最大组织稳态水平可能对豚鼠的健康最为适宜。
