西咪替丁预防肺酸性误吸（门德尔松）综合征

Cimetidine in the prevention of the pulmonary acid aspiration (Mendelson's) syndrome.

作者信息

Dobb G, Jordan M J, Williams J G

出版信息

Br J Anaesth. 1979 Oct;51(10):967-70. doi: 10.1093/bja/51.10.967.

DOI:10.1093/bja/51.10.967

Abstract

Cimetidine 200 mg was given i.v. 1 h before induction of anaesthesia to 20 patients about to undergo emergency surgery. There was an increase in pH of gastric aspirate in all patients (P less than 0.001) and in 80% pH was greater than 2.5 units at the time of induction of anaesthesia. The pH of gastric aspirate continued to increase after induction of anaesthesia and was greater than 4 units in all patients at the time of tracheal extubation and in the early recovery period.

摘要

对20名即将接受急诊手术的患者，在麻醉诱导前1小时静脉注射200毫克西咪替丁。所有患者的胃吸出物pH值均升高（P<0.001），80%的患者在麻醉诱导时pH值大于2.5。麻醉诱导后胃吸出物pH值持续升高，在气管拔管时及早期恢复期，所有患者的pH值均大于4。