Pickering B G, Palahniuk R J, Cumming M
Can Anaesth Soc J. 1980 Jan;27(1):33-5. doi: 10.1007/BF03006845.
A single intramuscular injection of Cimetidine was compared to oral antacid premedication in 17 patients undergoing elective Caesarean section. Seven patients in the Cimetidine group and four in the antacid group had gastric volumes in excess of 50 ml after induction of anaesthesia, while two patients in each group had gastric pH less than 2.5 after induction. Cimetidine was as effective as antacid in raising gastric pH but neither was completely reliable. This study reconfirms the high gastric volumes in pregnant patients with the need for preventative measures against aspiration during the induction of anaesthesia.
对17例行择期剖宫产手术的患者，将单次肌内注射西咪替丁与口服抗酸剂进行术前用药比较。西咪替丁组7例患者和抗酸剂组4例患者在麻醉诱导后胃内容量超过50 ml，而每组各有2例患者在诱导后胃pH值小于2.5。西咪替丁在提高胃pH值方面与抗酸剂效果相当，但两者都不完全可靠。本研究再次证实了妊娠患者胃内容量高，在麻醉诱导期间需要采取预防误吸的措施。
