Knudsen E T, Dewdney J M, Trafford J A
Br Med J. 1970 Feb 21;1(5694):469-71. doi: 10.1136/bmj.1.5694.469.
Purification of ampicillin (Penbritin) with respect to protein impurities has been found significantly to reduce the incidence of rashes in treated patients. This may be related to findings in animals that injections of the isolated protein impurity can induce the formation of circulating IgG antibodies and skin-sensitizing antibodies.
已发现，就蛋白质杂质而言，对氨苄西林（青霉素）进行纯化可显著降低接受治疗患者的皮疹发生率。这可能与在动物身上的发现有关，即注射分离出的蛋白质杂质可诱导循环IgG抗体和皮肤致敏抗体的形成。
