通过氨苄西林纯化降低氨苄西林皮疹的发生率。
Reduction in incidence of ampicillin rash by purification of ampicillin.
作者信息
Knudsen E T, Dewdney J M, Trafford J A
出版信息
Br Med J. 1970 Feb 21;1(5694):469-71. doi: 10.1136/bmj.1.5694.469.
Abstract
Purification of ampicillin (Penbritin) with respect to protein impurities has been found significantly to reduce the incidence of rashes in treated patients. This may be related to findings in animals that injections of the isolated protein impurity can induce the formation of circulating IgG antibodies and skin-sensitizing antibodies.
摘要
已发现，就蛋白质杂质而言，对氨苄西林（青霉素）进行纯化可显著降低接受治疗患者的皮疹发生率。这可能与在动物身上的发现有关，即注射分离出的蛋白质杂质可诱导循环IgG抗体和皮肤致敏抗体的形成。
相似文献
1
Reduction in incidence of ampicillin rash by purification of ampicillin.通过氨苄西林纯化降低氨苄西林皮疹的发生率。
Br Med J. 1970 Feb 21;1(5694):469-71. doi: 10.1136/bmj.1.5694.469.
2
Drug reactions. XIX. Adverse cutaneous reactions to the penicillins--ampicillin rashes.
Br J Dermatol. 1972 Sep;87(3):293-7. doi: 10.1111/j.1365-2133.1972.tb00328.x.
3
Reduction in incidence of rash using polymer-free ampicillin.使用无聚合物氨苄西林降低皮疹发生率。
Br Med J. 1976 Apr 24;1(6016):998. doi: 10.1136/bmj.1.6016.998.
4
Ampicillin rash in children. Relationship to penicillin allergy and infectious mononucleosis.儿童氨苄西林皮疹。与青霉素过敏及传染性单核细胞增多症的关系。
Am J Dis Child. 1973 Feb;125(2):187-90. doi: 10.1001/archpedi.1973.04160020023004.
5
An immunofluorescent study of the ampicillin rash.氨苄西林皮疹的免疫荧光研究。
Clin Allergy. 1982 May;12(3):279-80. doi: 10.1111/j.1365-2222.1982.tb02528.x.
6
Prospective study of ampicillin rash. Report of a collaborative study group.氨苄西林皮疹的前瞻性研究。协作研究小组报告。
Br Med J. 1973 Jan 6;1(5844):7-9.
7
Ampicillin-specific rashes.氨苄西林特异性皮疹。
Arch Fam Med. 1996 May;5(5):301-4. doi: 10.1001/archfami.5.5.301.
8
Skin reactions to ampicillin.氨苄西林引起的皮肤反应。
Br Med J. 1972 Feb 19;1(5798):505-6.
9
Rashes associated with intravenous administration of ampicillin.
Boll Ist Sieroter Milan. 1983 Jul;62(3):287-91.
10
[Incidence of ampicillin rashes in childhood (author's transl)].儿童期氨苄青霉素皮疹的发病率（作者译）
Monatsschr Kinderheilkd (1902). 1975 Jul;123(7):548-54.
引用本文的文献
1
Prospective study of ampicillin rash. Report of a collaborative study group.氨苄西林皮疹的前瞻性研究。协作研究小组报告。
Br Med J. 1973 Jan 6;1(5844):7-9.
2
The formation of antigenic polymers in aqueous solutions of -lactam antibiotics.β-内酰胺抗生素水溶液中抗原聚合物的形成。
Immunology. 1971 Sep;21(3):517-25.
3
IgM and IgG antibody levels to ampicillin in patients with infectious mononucleosis.传染性单核细胞增多症患者针对氨苄西林的IgM和IgG抗体水平。
Clin Exp Immunol. 1976 Nov;26(2):214-21.
4
Ampicillin rash.氨苄西林皮疹
West J Med. 1977 Apr;126(4):333-5.
5
Reduction in incidence of rash using polymer-free ampicillin.使用无聚合物氨苄西林降低皮疹发生率。
Br Med J. 1976 Apr 24;1(6016):998. doi: 10.1136/bmj.1.6016.998.
6
Editorial: Ampicillin rashes.社论：氨苄西林皮疹
Br Med J. 1975 Jun 28;2(5973):708-9.
本文引用的文献
1
THE SPECIFICITY OF HEMAGGLUTINATION REACTIONS IN HUMAN AND EXPERIMENTAL PENICILLIN HYPERSENSITIVITY.人类及实验性青霉素超敏反应中血凝反应的特异性
J Allergy. 1964 Sep-Oct;35:399-424. doi: 10.1016/0021-8707(64)90067-x.
2
COMPARISON OF AMPICILLIN AND CHLORAMPHENICOL IN TREATMENT OF PARATYPHOID FEVER.氨苄西林与氯霉素治疗副伤寒热的比较
Br Med J. 1964 Jan 18;1(5376):148-50. doi: 10.1136/bmj.1.5376.148.
3
Ampicillin and the fifth-day rash.氨苄西林与第五天出现的皮疹。
Br Med J. 1966 May 28;1(5499):1359. doi: 10.1136/bmj.1.5499.1359-b.
4
Treatment of common genitourinary tract infections with oral ampicillin.口服氨苄西林治疗常见的泌尿生殖道感染。
Curr Ther Res Clin Exp. 1967 Oct;9(10):497-503.
5
Drug rash with ampicillin and other penicillins.
Lancet. 1969 Nov 8;2(7628):969-72. doi: 10.1016/s0140-6736(69)90535-2.
6
Hypersensitivity reactions to antibacterial drugs in infectious mononucleosis.传染性单核细胞增多症对抗菌药物的超敏反应。
Lancet. 1967 Dec 2;2(7527):1176-8. doi: 10.1016/s0140-6736(67)91893-4.
7
Cutaneous sensitivity to purified benzylpenicillin.
Lancet. 1967 Jun 3;1(7501):1184-8. doi: 10.1016/s0140-6736(67)92840-1.
8
Allergenic residues in penicillins.青霉素中的致敏性残留物。
Lancet. 1967 Jun 3;1(7501):1177-83. doi: 10.1016/s0140-6736(67)92839-5.
9
A penicilloylated protein impurity as a source of allergy to benzylpenicillin and 6-aminopenicillanic acid.一种青霉酰化蛋白杂质，作为对苄青霉素和6-氨基青霉烷酸过敏的来源。
Lancet. 1967 Jun 3;1(7501):1175-7. doi: 10.1016/s0140-6736(67)92838-3.
Zotero 插件