Liebeskind D, Bases R, Elequin F, Neubort S, Leifer R, Goldberg R, Koenigsberg M
Radiology. 1979 Apr;131(1):177-84. doi: 10.1148/131.1.177.
The effects of diagnostic levels of ultrasound on DNA of HeLa cells included: increased immunoreactivity to antinucleoside antibodies in G1 cells, strongly suggestive of unwinding of the helix or single-strand break induction, and low levels of non-semiconservative synthesis in logarithmically growing cells treated with hydroxyurea, indicating repair synthesis. In the C3H mouse cell line 10T-1/2, Cl 8, loss of contact inhibition with a criss-crossed growth pattern was seen. In one experiment, tumors developed in syngeneic mice at the site of injection of ultrasonically treated cells. Ultrasound in the diagnostic range appears to cause detectable effects on DNA and growth patterns of animal cells.
诊断级超声对HeLa细胞DNA的影响包括：G1期细胞中抗核苷抗体的免疫反应性增加，强烈提示螺旋解旋或单链断裂诱导，以及在用羟基脲处理的对数生长期细胞中低水平的非半保留合成，表明存在修复合成。在C3H小鼠细胞系10T-1/2、Cl 8中，观察到失去接触抑制并出现交叉生长模式。在一项实验中，在注射经超声处理细胞的部位，同基因小鼠体内出现了肿瘤。诊断范围内的超声似乎会对动物细胞的DNA和生长模式产生可检测到的影响。
