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体外超声照射细胞的诊断超声延时及透射电子显微镜研究

Diagnostic ultrasound time-lapse and transmission electron microscopic studies of cells insonated in vitro.

作者信息

Liebeskind D, Padawer J, Wolley R, Bases R

出版信息

Br J Cancer Suppl. 1982 Mar;5:176-86.

PMID:6950757
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2149293/
Abstract

A fibroblast cell line (3T3) and normal rat peritoneal fluid cells were exposed in vitro to pulsed ultrasound from a diagnostic instrument (Smith-Kline "Ekoline 20"). We report here on ultrastructural changes in both cell types and on altered motility patterns in 3T3 fibroblasts. Abnormal motility was detectable 10 generations after exposure. X-irradiation and ultraviolet light elicited similar effects on cell motion. It is suggested that the cellular effects of diagnostic levels of ultrasound be further examined both in vitro and in vivo.

摘要

将成纤维细胞系（3T3）和正常大鼠腹腔液细胞在体外暴露于一台诊断仪器（史克必成公司的“Ekoline 20”）发出的脉冲超声。我们在此报告这两种细胞类型的超微结构变化以及3T3成纤维细胞运动模式的改变。暴露后10代可检测到异常运动。X射线照射和紫外线对细胞运动产生了类似影响。建议在体外和体内进一步研究诊断水平超声的细胞效应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e9c/2149293/871d3f0acdcf/brjcancersuppl00063-0193-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e9c/2149293/d546f24fe4dd/brjcancersuppl00063-0189-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e9c/2149293/9564eb2d1b84/brjcancersuppl00063-0186-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e9c/2149293/f404cd9e4684/brjcancersuppl00063-0187-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e9c/2149293/907eea58f8d3/brjcancersuppl00063-0188-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e9c/2149293/ecf445f8af77/brjcancersuppl00063-0190-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e9c/2149293/a5eef336c77b/brjcancersuppl00063-0191-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e9c/2149293/1d0251809b55/brjcancersuppl00063-0192-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e9c/2149293/871d3f0acdcf/brjcancersuppl00063-0193-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e9c/2149293/d546f24fe4dd/brjcancersuppl00063-0189-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e9c/2149293/9564eb2d1b84/brjcancersuppl00063-0186-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e9c/2149293/f404cd9e4684/brjcancersuppl00063-0187-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e9c/2149293/907eea58f8d3/brjcancersuppl00063-0188-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e9c/2149293/ecf445f8af77/brjcancersuppl00063-0190-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e9c/2149293/a5eef336c77b/brjcancersuppl00063-0191-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e9c/2149293/1d0251809b55/brjcancersuppl00063-0192-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e9c/2149293/871d3f0acdcf/brjcancersuppl00063-0193-a.jpg

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引用本文的文献

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本文引用的文献

1
Morphological changes in the surface characteristics of cultured cells after exposure to diagnostic ultrasound.暴露于诊断超声后培养细胞表面特征的形态学变化。
Radiology. 1981 Feb;138(2):419-23. doi: 10.1148/radiology.138.2.7455124.
2
Functional significance of perichromatin granule accumulation induced by cadmium chloride in isolated rat liver cells.氯化镉诱导分离的大鼠肝细胞中染色质外周颗粒积累的功能意义。
Exp Cell Res. 1980 Jul;128(1):47-58. doi: 10.1016/0014-4827(80)90385-7.
3
Has diagnostic ultrasound mutagenic effects?诊断性超声有诱变作用吗？
第6节——气体载体超声造影剂存在下的机械生物效应。美国超声医学学会。
J Ultrasound Med. 2000 Feb;19(2):120-42, 154-68. doi: 10.7863/jum.2000.19.2.120.
4
Section 4--bioeffects in tissues with gas bodies. American Institute of Ultrasound in Medicine.第4节——含气体组织中的生物效应。美国医学超声学会。
J Ultrasound Med. 2000 Feb;19(2):97-108, 154-68. doi: 10.7863/jum.2000.19.2.97.
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Routine ultrasonography in utero and subsequent handedness and neurological development.子宫内常规超声检查及随后的利手和神经发育
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Hum Genet. 1980;56(1):95-8. doi: 10.1007/BF00281576.
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Relationship between x-ray exposure and malignant transformation in C3H 10T1/2 cells.C3H 10T1/2细胞中X射线照射与恶性转化的关系。
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7262-6. doi: 10.1073/pnas.77.12.7262.
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Nuclear ultrastructure of epithelial cell lines derived from human carcinomas and nonmalignant tissues.
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Sister chromatid exchanges in human lymphocytes after exposure to diagnostic ultrasound.诊断性超声暴露后人淋巴细胞中的姐妹染色单体交换
Science. 1979 Sep 21;205(4412):1273-5. doi: 10.1126/science.472742.
7
Diagnostic ultrasound: effects on the DNA and growth patterns of animal cells.诊断超声：对动物细胞DNA和生长模式的影响
Radiology. 1979 Apr;131(1):177-84. doi: 10.1148/131.1.177.