组胺对大鼠离体、血液灌注小肠回肠区域收缩作用的药理学分析。
A pharmacological analysis of the contractile action of histamine upon the ileal region of the isolated, blood-perfused small intestine of the rat.
作者信息
Sakai K
出版信息
Br J Pharmacol. 1979 Dec;67(4):587-90. doi: 10.1111/j.1476-5381.1979.tb08705.x.
Abstract
- The mode of action of histamine was investigated on the rat isolated small intestine perfused at a fixed flow rate through the superior mesenteric artery with blood from the carotid artery of a heparinized donor rat. Compounds were closely injected into the superior mesenteric artery. 2. Increasing doses (1 to 100 micrograms) of histamine caused a monophasic fast contraction of the ileum. 3. The fast contraction was abolished by tetrodotoxin, hexamethonium, morphine or mepyramine, but was not prevented by atropine. 4. The present study indicates that histamine produces the fast contraction of the ileum by primarily acting on the myenteric nerve plexus involving cholinergic interneurones.
摘要
- 采用如下方法研究组胺的作用方式：将肝素化供体大鼠颈动脉血以固定流速经肠系膜上动脉灌注到离体大鼠小肠。化合物经肠系膜上动脉近端注入。2. 递增剂量（1至100微克）的组胺引起回肠单相快速收缩。3. 河豚毒素、六甲铵、吗啡或美吡拉敏可消除该快速收缩，但阿托品不能阻止。4. 本研究表明，组胺主要通过作用于包含胆碱能中间神经元的肌间神经丛，引起回肠快速收缩。
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