母乳性黄疸：3-α 20-β-孕二醇对人肝脏胆红素结合的影响
Breast milk jaundice: effect of 3-alpha 20-beta-pregnanediol on bilirubin conjugation by human liver.
作者信息
Adlard B P, Lathe G H
出版信息
Arch Dis Child. 1970 Apr;45(240):186-9. doi: 10.1136/adc.45.240.186.
Abstract
The effect of 3α,20β-pregnanediol and other steroids on bilirubin conjugation was examined using liver tissue from human and four other species. Neither 3α,20β-pregnanediol nor 3α,20β-pregnanediol inhibited conjugation by human liver slices or by solubilized human liver microsomes. 3α,20β-pregnanediol is unlikely to be the inhibitor causing breast milk jaundice. Oestriol inhibited conjugation by human liver slices. A comparison of species indicated that the response of the human liver slice system to steroids resembles that of the rabbit and guinea-pig rather than the rat or mouse.
摘要
使用人类和其他四种物种的肝脏组织，研究了3α,20β-孕二醇和其他类固醇对胆红素结合的影响。3α,20β-孕二醇和3α,20β-孕二醇均未抑制人肝切片或溶解的人肝微粒体的结合。3α,20β-孕二醇不太可能是导致母乳性黄疸的抑制剂。雌三醇抑制人肝切片的结合。物种比较表明，人肝切片系统对类固醇的反应类似于兔子和豚鼠，而不是大鼠或小鼠。
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本文引用的文献
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