Castrup H J, Reiss A, Neumann K
Res Exp Med (Berl). 1979 Feb 6;174(2):159-67. doi: 10.1007/BF01851328.
The influence of Methylprednisolone (1.2 mg/kg body weight daily for 14 days) on the physiological cell renewal of gastric and intestinal mucosa was examined autoradiographically by determination of the 3H-labelling index and the cell cycle of the regenerating epithelial cells. Macroscopical or microscopical changes of the gastric or intestinal mucosa could not be observed. The labelling index was not significantly altered compared to the controls. Against this the determination of the cell cycle showed a clear inhibition of epithelial cell proliferation in all parts of the gastrointestinal tract with a prolongation of the postmitotic phase, a small inhibition of the DNA synthesis and a corresponding prolongation of the mean generation time.
通过测定³H标记指数和再生上皮细胞的细胞周期，采用放射自显影法研究了甲基强的松龙（每日1.2mg/kg体重，共14天）对胃和肠黏膜生理细胞更新的影响。未观察到胃或肠黏膜的宏观或微观变化。与对照组相比，标记指数无明显改变。与此相反，细胞周期测定显示胃肠道各部位上皮细胞增殖明显受到抑制，有丝分裂后阶段延长，DNA合成受到轻微抑制，平均生成时间相应延长。
