唐氏综合征及长期抗惊厥治疗期间的大细胞性贫血。
Macrocytosis in Down's syndrome and during long-term anticonvulsant therapy.
作者信息
Eastham R D, Jancar J
出版信息
J Clin Pathol. 1970 May;23(4):296-8. doi: 10.1136/jcp.23.4.296.
Abstract
In a group of non-anaemic mentally retarded patients a significant increase in mean red cell volume has been demonstrated in epileptic patients being treated with anticonvulsants. The possible sites of interference of anticonvulsants with folate activity in the body, and problems associated with folic acid supplements during anticonvulsant therapy, are discussed. During the survey it was confirmed that the mean red cell volume is abnormally increased in many cases of Down's syndrome.
摘要
在一组非贫血的智障患者中，已证实用抗惊厥药治疗的癫痫患者平均红细胞体积显著增加。文中讨论了抗惊厥药在体内干扰叶酸活性的可能部位，以及抗惊厥治疗期间与叶酸补充剂相关的问题。在调查过程中证实，唐氏综合征的许多病例中平均红细胞体积异常增加。
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