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Macrocytosis in Down's syndrome and during long-term anticonvulsant therapy.唐氏综合征及长期抗惊厥治疗期间的大细胞性贫血。
J Clin Pathol. 1970 May;23(4):296-8. doi: 10.1136/jcp.23.4.296.
2
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Leucocyte ultrastructure and folate metabolism in Down's syndrome.唐氏综合征患者的白细胞超微结构与叶酸代谢
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Comparative and serial assays of folate metabolism in anticonvulsant-treated epileptics.抗惊厥治疗的癫痫患者叶酸代谢的比较及系列检测
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Assignment of the human gene for liver-type 6-phosphofructokinase isozyme (PFKL) to chromosome 21 by using somatic cell hybrids and monoclonal anti-L antibody.利用体细胞杂种和抗L单克隆抗体将人类肝型6-磷酸果糖激酶同工酶（PFKL）基因定位于21号染色体。
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本文引用的文献

1
Serum folic-acid and vitamin-B12 levels in anticonvulsant therapy.抗惊厥治疗中的血清叶酸和维生素B12水平
Br Med J. 1966 Apr 16;1(5493):955-7. doi: 10.1136/bmj.1.5493.955.
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STUDIES OF FOLATE DEFICIENCY IN MAN.人体叶酸缺乏研究。
Proc R Soc Med. 1964 May;57(5):377-84. doi: 10.1177/003591576405700516.
3
SUBNORMAL SERUM FOLATE AND MACROCYTOSIS ASSOCIATED WITH ANTICONVULSANT DRUG THERAPY.与抗惊厥药物治疗相关的血清叶酸水平低下和大细胞性贫血
Blood. 1964 Jan;23:68-86.
4
Interrelations of vitamin B12 and folic acid metabolism: folic acid clearance studies.维生素B12与叶酸代谢的相互关系：叶酸清除率研究
J Clin Invest. 1962 Jun;41(6):1263-76. doi: 10.1172/JCI104589.
5
Anticonvulsant-associated megaloblastic anemia. Response to 25 microgm. of folic acid administered by mouth daily.抗惊厥药相关性巨幼细胞贫血。对每日口服25微克叶酸的反应。
N Engl J Med. 1962 Sep 6;267:483-5. doi: 10.1056/NEJM196209062671004.
6
Folic acid deficiency and the megaloblastic anaemias.叶酸缺乏与巨幼细胞贫血
Proc R Soc Med. 1958 Sep;51(9):757-63. doi: 10.1177/003591575805100916.
7
Macrocytosis and macrocytic anaemia caused by anticonvulsant drugs.
Q J Med. 1958 Jan;27(105):45-63.
8
Megaloblastic anaemia occurring during primidone therapy.扑米酮治疗期间发生的巨幼细胞贫血。
Br Med J. 1956 Jan 21;1(4959):146-7. doi: 10.1136/bmj.1.4959.146.
9
Studies on deficiency and absorption of folates in patients on anticonvulsant drugs.抗惊厥药物治疗患者叶酸缺乏与吸收的研究。
Australas Ann Med. 1967 May;16(2):144-50. doi: 10.1111/imj.1967.16.2.144.
10
Malabsorption of folic acid due to diphenylhydantoin.由苯妥英钠引起的叶酸吸收不良。
Blood. 1967 Sep;30(3):341-51.

唐氏综合征及长期抗惊厥治疗期间的大细胞性贫血。

Macrocytosis in Down's syndrome and during long-term anticonvulsant therapy.

作者信息

Eastham R D, Jancar J

出版信息

J Clin Pathol. 1970 May;23(4):296-8. doi: 10.1136/jcp.23.4.296.

DOI:10.1136/jcp.23.4.296
PMID:4246925
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC476746/
Abstract

In a group of non-anaemic mentally retarded patients a significant increase in mean red cell volume has been demonstrated in epileptic patients being treated with anticonvulsants. The possible sites of interference of anticonvulsants with folate activity in the body, and problems associated with folic acid supplements during anticonvulsant therapy, are discussed. During the survey it was confirmed that the mean red cell volume is abnormally increased in many cases of Down's syndrome.

摘要

在一组非贫血的智障患者中，已证实用抗惊厥药治疗的癫痫患者平均红细胞体积显著增加。文中讨论了抗惊厥药在体内干扰叶酸活性的可能部位，以及抗惊厥治疗期间与叶酸补充剂相关的问题。在调查过程中证实，唐氏综合征的许多病例中平均红细胞体积异常增加。