Wachtel T J, Pueschel S M
Division of General Internal Medicine, Rhode Island Hospital, Providence 02903.
Am J Ment Retard. 1991 Jan;95(4):417-20.
The mean corpuscular volume of erythrocytes in persons with Down syndrome is larger than normal in the absence of anemia. The mean mean corpuscular volume among our 61 subjects with trisomy 21 was 99.08 fl (range = 90 to 107). Red blood cell survival half-time was substantially shorter than normal in many of these patients. These findings suggest that erythrocytes have a younger mean age in persons with Down syndrome. The increased red blood cell turnover in this population may indicate an accelerated aging process of red blood cells.
唐氏综合征患者在无贫血情况下红细胞的平均体积大于正常水平。在我们61名21三体综合征受试者中，平均红细胞体积为99.08飞升（范围为90至107）。许多这类患者的红细胞存活半衰期明显短于正常水平。这些发现表明，唐氏综合征患者红细胞的平均年龄较轻。该人群中红细胞周转率增加可能表明红细胞衰老过程加速。
