Silverberg G D, Britt R H
West J Med. 1979 Mar;130(3):191-5.
The cases of 70 consecutive patients having a transsphenoidal hypophysectomy for metastatic carcinoma of the breast or prostate are reviewed. In half of the patients with cancer of the breast an objective remission was obtained. In 30 percent of the patients with cancer of the prostate there were objective signs of tumor regression and in 75 percent there was relief of pain. The operative mortality was 1.4 percent and the morbidity of the procedure was gratifyingly small. There is some indication that hypophysectomy may be preferred to adrenalectomy in patients with hormone-responsive metastatic mammary cancer.
回顾了70例因乳腺癌或前列腺癌行经蝶窦垂体切除术的连续病例。在一半的乳腺癌患者中获得了客观缓解。在30%的前列腺癌患者中出现了肿瘤消退的客观体征，75%的患者疼痛得到缓解。手术死亡率为1.4%，手术并发症发生率低得令人满意。有迹象表明，对于激素反应性转移性乳腺癌患者，垂体切除术可能比肾上腺切除术更可取。
