去甲肾上腺素和5-羟色胺在四氢萘胺诱导的大鼠体温变化中的作用。
Role of noradrenaline and 5-hydroxytryptamine in tetrahydronaphthylamine-induced temperature changes in the rat.
作者信息
Bruinvels J, Kemper G C
出版信息
Br J Pharmacol. 1971 Sep;43(1):1-9. doi: 10.1111/j.1476-5381.1971.tb07151.x.
Abstract
- Intraperitoneal administration of graded doses of tetrahydronaphthylamine (THN) to rats caused a dose dependent decrease in body temperature.2. Intracisternal injection of graded doses of THN induced hypothermia, and implantation of crystalline THN rostral to the medial preoptic area and caudal to the striatum, caused hyperthermia.3. Pretreatment of the rats with a MAO inhibitor changed the hypothermia into hyperthermia.4. Intraperitoneal injection of 5-hydroxytryptophan caused a hypothermia which could be reversed into hyperthermia when the rats were pretreated with a MAO inhibitor.5. Pretreatment with parachlorophenylalanine enhanced the THN-induced hypothermia.6. Depletion of brain monoamines by Ro-4-1284 in combination with an inhibition of the biosynthesis of noradrenaline (diethyldithiocarbamate) changed the THN-induced hypothermia into hyperthermia.7. It is concluded that THN affects body temperature in rats by two central mechanisms, viz. a decrease mediated by noradrenaline, probably in the hypothalamus, and an increase which might be mediated by 5-hydroxytryptamine rostral to the medial preoptic area.
摘要
向大鼠腹腔注射不同剂量的四氢萘胺（THN）会导致体温呈剂量依赖性下降。
向大鼠脑池内注射不同剂量的THN会诱发体温过低，而将结晶状THN植入视前内侧区前方和纹状体后方会导致体温过高。
用单胺氧化酶抑制剂对大鼠进行预处理会使体温过低转变为体温过高。
腹腔注射5-羟色氨酸会导致体温过低，而当用单胺氧化酶抑制剂对大鼠进行预处理时，这种体温过低可转变为体温过高。
用对氯苯丙氨酸进行预处理会增强THN诱发的体温过低。
用Ro-4-1284耗竭脑单胺并联合抑制去甲肾上腺素的生物合成（二乙基二硫代氨基甲酸盐）会使THN诱发的体温过低转变为体温过高。
得出的结论是，THN通过两种中枢机制影响大鼠的体温，即一种可能由下丘脑的去甲肾上腺素介导的体温下降，以及一种可能由视前内侧区前方的5-羟色胺介导的体温升高。
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本文引用的文献
1
A NEW CONCEPT OF TEMPERATURE REGULATION BY AMINES IN THE HYPOTHALAMUS.下丘脑胺类物质调节体温的新概念。
Nature. 1963 Dec 28;200:1325. doi: 10.1038/2001325a0.
2
Temperature responses to monoamines and an inhibitor of MAO injected into the cerebral ventricles of rats.对注入大鼠脑室的单胺类物质和单胺氧化酶抑制剂的温度反应。
Br J Pharmacol Chemother. 1967 Sep;31(1):152-61. doi: 10.1111/j.1476-5381.1967.tb01985.x.
3
Site of action of dopamine and apomorphine on compulsive gnawing behaviour in rats.多巴胺和阿扑吗啡对大鼠强迫性啃咬行为的作用部位。
Experientia. 1966 Dec 15;22(12):837-8. doi: 10.1007/BF01897450.
4
Influence of drugs on the temperature-lowering effect of harmaline.药物对骆驼蓬碱降温作用的影响。
Eur J Pharmacol. 1968 Aug;4(1):31-9. doi: 10.1016/0014-2999(68)90006-x.
5
The effects of p-chlorophenylalanine, a serotonin depletor, on avoidance acquisition, pain sensitivity and related behavior in the rat.对氯苯丙氨酸（一种血清素消耗剂）对大鼠回避学习、痛觉敏感性及相关行为的影响。
Psychopharmacologia. 1967;10(3):204-19. doi: 10.1007/BF00401382.
6
Effect of noradrenaline, dopamine and 5-hydroxytryptamine on body temperature in the rat after intracisternal administration.脑池内注射去甲肾上腺素、多巴胺和5-羟色胺对大鼠体温的影响。
Neuropharmacology. 1970 May;9(3):277-82. doi: 10.1016/0028-3908(70)90077-8.
7
Effect of tetrahydro-beta-naphtylamine on body temperature in rats.四氢-β-萘胺对大鼠体温的影响。
Arch Int Pharmacodyn Ther. 1969 Dec;182(2):414-5.
8
p-Chlorophenylalanine: a specific depletor of brain serotonin.对氯苯丙氨酸：一种脑血清素的特异性耗竭剂。
J Pharmacol Exp Ther. 1966 Dec;154(3):499-516.
9
Comparison of intracisternally and intraperitoneally injected harmaline on body temperature and tremor in the rat.脑池内注射与腹腔内注射哈马灵对大鼠体温和震颤的比较。
J Pharm Pharmacol. 1969 Aug;21(8):506-8. doi: 10.1111/j.2042-7158.1969.tb08302.x.
10
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J Pharm Pharmacol. 1966 Jan;18(1):60-2. doi: 10.1111/j.2042-7158.1966.tb07773.x.
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