5-羟色胺和去甲肾上腺素在大鼠发热中的不同作用
Contrasting roles of 5-hydroxytryptamine and noradrenaline in fever in rats.
作者信息
Ford D M, Klugman K P
出版信息
J Physiol. 1980 Jul;304:51-7. doi: 10.1113/jphysiol.1980.sp013309.
Abstract
- We have investigated the effects of endogenous monoamine depletion on the development of fever in rats. 2. Fever was produced in rats by a single intraperitoneal injection of Salmonella typhosa endotoxin or leucocyte pyrogen manufactured from ox blood. 3. Depletion of brain 5-hydroxytryptamine (5-HT) by pretreatment with p-chlorophenylalanine prevented the rise in rectal temperature produced both by bacterial endotoxin and by leucocyte pyrogen. 4. On the other hand depletion of noradrenaline (NA) by 6-hydroxydopamine pretreatment resulted in a potentiation of the fever produced by bacterial endotoxin. 5. These results suggest that 5-HT is involved in mechanisms responsible for the rise in temperature during fever and that NA is involved in mechanisms which serve to attenuate the rise.
摘要
- 我们研究了内源性单胺耗竭对大鼠发热发展的影响。2. 通过单次腹腔注射伤寒沙门氏菌内毒素或由牛血制成的白细胞热原在大鼠中引起发热。3. 用对氯苯丙氨酸预处理使脑5-羟色胺（5-HT）耗竭，可防止细菌内毒素和白细胞热原引起的直肠温度升高。4. 另一方面，用6-羟基多巴胺预处理使去甲肾上腺素（NA）耗竭，会导致细菌内毒素引起的发热增强。5. 这些结果表明，5-HT参与了发热时体温升高的机制，而NA参与了有助于减轻体温升高的机制。
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本文引用的文献
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Body mass and sex as determining factors in the development of fever in rats.体重和性别作为大鼠发热发展的决定因素。
J Physiol. 1980 Jul;304:43-50. doi: 10.1113/jphysiol.1980.sp013308.
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p-Chlorophenylalanine: a specific depletor of brain serotonin.对氯苯丙氨酸：一种脑血清素的特异性耗竭剂。
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Thermoregulatory effects of intrahypothalamic injections of adrenergic and cholinergic substances at different environmental temperatures.在不同环境温度下，下丘脑内注射肾上腺素能和胆碱能物质的体温调节效应。
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Neural release of brain serotonin and body temperature.大脑血清素的神经释放与体温
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