[Dynamics of components of the kallikrein-kinin system in the arterial and venous blood and cerebrospinal fluid of patients with severe cranio-cerebral injuries].

Comparative study of the activity dynamics of the components of the kallikrein-kinin system in portions of blood flowing to the brain and draining from it and in the cerebrospinal fluid was carried out in 26 patients with a severe craniocerebral trauma. It was found that activation of the system is displayed by a considerable increase in spontaneous esterase activity, a fall in the activity of kallikrein inhibitors, and a decrease in the content of prekallikrein and kininogen. The degree of activation depends on the severity of the lesion, reaches the maximum level by the 3rd--4th day of the development of the pathological process, and is manifested most fully in blood draining from the brain.