Pirotte J
Biomedicine. 1980 Feb;32(1):17-21.
The plasma disappearance curve following a single intravenous injection of a tracer dose of 131I-labelled Rose Bengal (131I RB) is used to calculate the parameters of a three-compartmental model. In the model proposed, plasma 131I RB exchanges with two additional pools, one of which is thought to represent extrahepatic extravascular compartment (compartment 2) and the other the liver (compartment 3). 131I RB is assumed to be eliminated from the system solely from compartment 3 by secretion into bile, and no urinary excretion is taken into consideration. The assumptions implicit in the model (no excretion of 131 I RB in urine, reflux from liver to plasma, exchange with extravascular extraphepatic compartment, identification of compartments 2 and 3 respectively as extravascular extrahepatic, and intraphepatic) are supported by a set of experimental data.
单次静脉注射示踪剂量的131I标记玫瑰红（131I RB）后的血浆消失曲线用于计算三室模型的参数。在所提出的模型中，血浆131I RB与另外两个池进行交换，其中一个被认为代表肝外血管外隔室（隔室2），另一个代表肝脏（隔室3）。假设131I RB仅通过胆汁分泌从隔室3排出系统，未考虑尿液排泄。该模型中隐含的假设（131I RB不通过尿液排泄、从肝脏回流到血浆、与血管外肝外隔室交换、分别将隔室2和3识别为血管外肝外和肝内）得到了一组实验数据的支持。
