角膜中液体泵的代谢基础。
The metabolic basis to the fluid pump in the cornea.
作者信息
Dikstein S, Maurice D M
出版信息
J Physiol. 1972 Feb;221(1):29-41. doi: 10.1113/jphysiol.1972.sp009736.
Abstract
- A technique for isolating and perfusing the rabbit cornea is described, which allowed its thickness to be continuously measured under the microscope. The reversal of thickness of the cold-swollen cornea on perfusion with various solutions at 37 degrees C was studied.2. It was found that only a combination of adenosine and glutathione was able to reliably reverse the thickness to its normal value. This mechanism is sodium, bicarbonate, and oxygen dependent. Inhibitors of glycolysis or electron transport stop the reversal process.3. The findings are consistent with a need for an ATPase but are not capable of distinguishing among several possibilities for its regulation.
摘要
描述了一种分离和灌注兔角膜的技术，该技术能在显微镜下连续测量其厚度。研究了在37摄氏度下用各种溶液灌注时冷肿胀角膜厚度的逆转情况。
发现只有腺苷和谷胱甘肽的组合能够可靠地将厚度逆转至正常值。该机制依赖于钠、碳酸氢盐和氧气。糖酵解或电子传递的抑制剂会阻止逆转过程。
这些发现与需要一种ATP酶一致，但无法区分其调节的几种可能性。
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The metabolic basis to the fluid pump in the cornea.角膜中液体泵的代谢基础。
J Physiol. 1972 Feb;221(1):29-41. doi: 10.1113/jphysiol.1972.sp009736.
2
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3
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A theory of endothelial control of corneal hydration.
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