放线菌素D：对鸡胚细胞中磷脂合成的抑制作用。
Actinomycin D: inhibition of phospholipid synthesis in chick embryo cells.
作者信息
Pastan I, Friedman R M
出版信息
Science. 1968 Apr 19;160(3825):316-7. doi: 10.1126/science.160.3825.316.
PMID:5641263
Abstract
When chick embryo fibroblasts are exposed to actinomycin D for 30 minutes to 3 hours, there is progressive inhibition of phospholipid synthesis, so that by 3 hours the inhibition is 40 percent. All phospholipids are affected. Since this inhibition is twice as great as the inhibition of protein synthesis, some effects of actinomycin D previously ascribed to decreased protein synthesis must be reevaluated.
摘要
当鸡胚成纤维细胞暴露于放线菌素D 30分钟至3小时时，磷脂合成会逐渐受到抑制，到3小时时抑制率达到40%。所有磷脂均受影响。由于这种抑制作用是蛋白质合成抑制作用的两倍，因此必须重新评估先前归因于蛋白质合成减少的放线菌素D的某些作用。
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