鼠伤寒沙门氏菌对嘧啶和嘧啶核苷的代谢
Metabolism of pyrimidines and pyrimidine nucleosides by Salmonella typhimurium.
作者信息
Beck C F, Ingraham J L, Neuhard J, Thomassen E
出版信息
J Bacteriol. 1972 Apr;110(1):219-28. doi: 10.1128/jb.110.1.219-228.1972.
Abstract
The pathways by which uracil, cytosine, uridine, cytidine, deoxyuridine, and deoxycytidine are metabolized by Salmonella typhimurium are established. The various 5-fluoropyrimidine analogues are shown to exert their toxic effects only after having been converted to the nucleotide level, and these conversions are shown to be catalyzed by the same enzymes which similarly convert the natural substrates. Methods for isolating mutant strains blocked in various steps of metabolism of pyrimidine bases and nucleosides are described.
摘要
鼠伤寒沙门氏菌代谢尿嘧啶、胞嘧啶、尿苷、胞苷、脱氧尿苷和脱氧胞苷的途径已明确。各种5-氟嘧啶类似物只有在转化为核苷酸水平后才会发挥其毒性作用，并且这些转化过程是由与天然底物类似转化过程相同的酶催化的。本文描述了分离嘧啶碱基和核苷代谢各步骤受阻的突变菌株的方法。
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本文引用的文献
1
THE MODE OF ACTION OF 5-FLUOROURACIL AND ITS DERIVATIVES.5-氟尿嘧啶及其衍生物的作用模式。
Proc Natl Acad Sci U S A. 1958 Oct 15;44(10):1004-12. doi: 10.1073/pnas.44.10.1004.
2
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
3
The metabolism of exogenously supplied nucleotides by Escherichia coli.大肠杆菌对外源供应核苷酸的代谢。
J Biol Chem. 1960 Feb;235:457-65.
4
Massive incorporation of 5-fluorouracil into a bacterial ribonucleic acid.5-氟尿嘧啶大量掺入细菌核糖核酸中。
Nature. 1959 Oct 17;184:1213-5. doi: 10.1038/1841213a0.
5
IMPROVED METHOD FOR THE ISOLATION OF THYMINE-REQUIRING MUTANTS OF ESCHERICHIA COLI.改进的大肠杆菌胸腺嘧啶需求突变体分离方法。
J Bacteriol. 1965 Aug;90(2):554-5. doi: 10.1128/jb.90.2.554-555.1965.
6
FEEDBACK INHIBITION OF URIDINE KINASE BY CYTIDINE TRIPHOSPHATE AND URIDINE TRIPHOSPHATE.胞苷三磷酸和尿苷三磷酸对尿苷激酶的反馈抑制作用
Biochim Biophys Acta. 1964 Nov 15;91:380-6. doi: 10.1016/0926-6550(64)90067-2.
7
ION-EXCHANGE CHROMATOGRAPHY OF NUCLEOTIDES ON POLY-(ETHYLENEIMINE)-CELLULOSE THIN LAYERS.核苷酸在聚（乙烯亚胺）-纤维素薄层上的离子交换色谱法
J Chromatogr. 1964 Oct;16:111-25. doi: 10.1016/s0021-9673(01)82445-6.
8
DEOXYTHYMIDINE KINASE OF ESCHERICHIA COLI. I. PURIFICATION AND SOME PROPERTIES OF THE ENZYME.大肠杆菌的脱氧胸苷激酶。I. 酶的纯化及某些性质
J Biol Chem. 1964 Jan;239:269-74.
9
Purification and properties of a pyrimidine deoxyriboside phosphorylase from Escherichia coli.来自大肠杆菌的嘧啶脱氧核糖核苷磷酸化酶的纯化及性质
Biochim Biophys Acta. 1958 Jun;28(3):562-6. doi: 10.1016/0006-3002(58)90519-5.
10
Utilization of purine and pyrimidine compounds in nucleic acid synthesis by Escherichia coli.大肠杆菌在核酸合成中对嘌呤和嘧啶化合物的利用。
Biochim Biophys Acta. 1954 Mar;13(3):381-5. doi: 10.1016/0006-3002(54)90345-5.
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