棒状杆菌属的产氨短杆菌和藤黄微球菌中嘧啶碱基和核苷的代谢
Metabolism of pyrimidine bases and nucleosides in the coryneform bacteria Brevibacterium ammoniagenes and Micrococcus luteus.
作者信息
Auling G, Moss B
出版信息
J Bacteriol. 1984 May;158(2):733-6. doi: 10.1128/jb.158.2.733-736.1984.
Abstract
The metabolism of exogenous pyrimidine bases and nucleosides was investigated in Brevibacterium ammoniagenes and Micrococcus luteus with fluorinated analogs and radioactive precursors. Salvage of thymine and thymidine was found in M. luteus, but not in B. ammoniagenes. Exogenous uracil or uracil nucleosides, but not cytosine or cytosine nucleosides, were nucleic acid precursors for both bacteria. By examining the possible nucleoside-metabolizing enzymes, it can be suggested that the pyrimidine salvage pathways in the coryneform bacteria are different from those of members of the family Enterobacteriaceae.
摘要
利用氟化类似物和放射性前体，研究了产氨短杆菌和藤黄微球菌中外源嘧啶碱基和核苷的代谢。在藤黄微球菌中发现了胸腺嘧啶和胸苷的补救途径，但在产氨短杆菌中未发现。外源尿嘧啶或尿嘧啶核苷是这两种细菌的核酸前体，而胞嘧啶或胞嘧啶核苷则不是。通过研究可能的核苷代谢酶，可以推测棒状杆菌中的嘧啶补救途径与肠杆菌科成员的不同。
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