粗糙脉孢菌中线粒体和细胞核基因在指定线粒体遗传装置方面的协作。
Cooperation of mitochondrial and nuclear genes specifying the mitochondrial genetic apparatus in Neurospora crassa.
作者信息
Barath Z, Küntzel H
出版信息
Proc Natl Acad Sci U S A. 1972 Jun;69(6):1371-4. doi: 10.1073/pnas.69.6.1371.
Abstract
Enzymes involved in the expression of the mitochondrial genome in Neurospora crassa are induced by chloramphenicol and ethidium bromide, which block transcription and translation of mitochondrial DNA. It is concluded that most, if not all, proteins of the mitochondrial genetic apparatus are coded by nuclear genes, synthesized on cytoplasmic ribosomes, and controlled by a repressor-like mitochondrial gene product. A model explaining the coordination of nuclear and mitochondrial division cycles by repressor control is discussed.
摘要
粗糙脉孢菌中线粒体基因组表达所涉及的酶可被氯霉素和溴化乙锭诱导，这两种物质会阻断线粒体DNA的转录和翻译。得出的结论是，线粒体遗传装置的大多数（如果不是全部）蛋白质由核基因编码，在细胞质核糖体上合成，并受一种类似阻遏物的线粒体基因产物控制。讨论了一个通过阻遏物控制来解释核与线粒体分裂周期协调的模型。
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