粗糙脉孢菌中的同步线粒体分裂。
Synchronous mitochondrial division in Neurospora crassa.
作者信息
Hawley E S, Wagner R P
出版信息
J Cell Biol. 1967 Dec;35(3):489-99. doi: 10.1083/jcb.35.3.489.
Abstract
Samples of mycelium of Neurospora crassa of known age were harvested from agar plates and examined with the electron microscope. The relative volume of the mitochondria was determined for mycelium of different ages. The volume measurements indicated that the mitochondria were dividing synchronously in fronts 6, 13, and 22(1/2) hr behind the growing hyphal tips. The sequence of mitochondrial division is hypothesized to include mitochondrial cupping followed by division which results in closely associated daughter mitochondria. On the basis of percentages of mitochondrial cupping and association, mitochondrial division was postulated to be occurring at 6, 14, and 26 hr. Close agreement between the mycelial mass doubling time and the calculated mitochondrial mass doubling time indicates that synchronous mitochondrial division is sufficient to maintain growth. The possibility that mitochondrial division is due to intercellular regulation of a mitochondrial genetic system is advanced.
摘要
从琼脂平板上收获已知生长时间的粗糙脉孢菌的菌丝体样本，并用电镜进行观察。测定了不同生长时间的菌丝体中线粒体的相对体积。体积测量结果表明，线粒体在生长菌丝尖端后方6小时、13小时和22.5小时处同步分裂。推测线粒体分裂的过程包括线粒体凹陷，随后分裂，产生紧密相连的子线粒体。根据线粒体凹陷和相连的百分比，推测线粒体分裂发生在6小时、14小时和26小时。菌丝体质量加倍时间与计算得出的线粒体质量加倍时间非常吻合，这表明线粒体同步分裂足以维持生长。有人提出线粒体分裂可能是由于线粒体遗传系统的细胞间调控所致。
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