传染性萎缩性鼻炎发病机制的一种推测性机制。
A suggested mechanism for the pathogenesis of infectious atrophic rhinitis.
作者信息
Harris D L, Switzer W P, Harris R A
出版信息
Can J Comp Med. 1971 Oct;35(4):318-23.
Abstract
Boivin extracts of Bordetella bronchiseptica inhibited or uncoupled the energized processes of bovine heart and pig heart mitochondria. Energy-dependent accumulation of calcium phosphate by both types of mitochondria was markedly inhibited by the extracts. The thesis is advanced that Boivin extracts of B. bronchiseptica may contain the membrane-damaging component responsible for infectious atrophic rhinitis. The action of the extracts was decreased by heat but seemed rather insensitive to digestion by trypsin or extraction by lipid solvents. Attempts to resolve the active component from the extracts were unsuccessful.
摘要
支气管败血波氏杆菌的博伊文提取物抑制或解偶联了牛心和猪心线粒体的能量代谢过程。两种类型的线粒体对磷酸钙的能量依赖性积累均被提取物显著抑制。有人提出这样的论点，即支气管败血波氏杆菌的博伊文提取物可能含有导致传染性萎缩性鼻炎的膜损伤成分。提取物的作用受热影响而降低，但似乎对胰蛋白酶消化或脂质溶剂提取不太敏感。从提取物中分离活性成分的尝试未成功。
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本文引用的文献
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Bordetella bronchiseptica-induced porcine atrophic rhinitis.支气管败血波氏杆菌引起的猪萎缩性鼻炎
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Bacterial pyrogens.细菌热原质
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Studies on the electron transfer system. IV. The electron transfer particle.电子传递系统研究。IV. 电子传递颗粒。
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