Brandenburg A C
Can J Comp Med. 1978 Jan;42(1):23-8.
The nasal and serum antibody response of two groups of pigs, vaccinated with adjuvant containing formalinized or sonicated Bordetella bronchiseptica bacterins was compared with the response of a nonvaccinated group. The tube agglutination test was used to determine agglutinin titers. Following vaccination, all pigs were challenged intranasally with the vaccine strain of Bordetella, after which the nasal Bordetella flora of vaccinated and nonvaccinated pigs was investigated. Sera and nasal secretions from both vaccinated groups exhibited markedly higher agglutinin titers than the control group and serum titers were higher than those in nasal secretions. No differences in agglutinating antibody response were evident between the two vaccines. Serum antibody titers exceeded nasal titers and persisted over a longer period of time. Systemic vaccination resulted in an increased nasal clearance of the vaccine strain by the groups of pigs vaccinated with sonicated or formalined bacterin, whereas no such clearance was evident in the nonvaccinated control group.
将两组接种含甲醛灭活或超声破碎支气管败血波氏杆菌菌苗佐剂的猪的鼻腔和血清抗体反应，与未接种组的反应进行了比较。采用试管凝集试验测定凝集素效价。接种疫苗后，所有猪经鼻用支气管败血波氏杆菌疫苗株进行攻毒，之后对接种和未接种猪的鼻腔波氏杆菌菌群进行了调查。两个接种组的血清和鼻腔分泌物的凝集素效价均显著高于对照组，且血清效价高于鼻腔分泌物中的效价。两种疫苗之间的凝集抗体反应无明显差异。血清抗体效价超过鼻腔效价且持续时间更长。用超声破碎或甲醛处理菌苗接种的猪组经全身接种后，疫苗株在鼻腔的清除率增加，而未接种的对照组则未出现这种清除现象。
