Rivinus T M, Harmatz J S
Am J Psychiatry. 1979 Apr;136(4B):551-4.
The authors report on five institutionalized retarded patients who had symptoms strongly suggestive of manic-depressive illness and who showed significant symptom reduction in a single-blind placebo-controlled three-year trial of lithium. The number of illness episodes was reduced, and symptoms decreased in all major illness dimensions. These findings indicate that major affective disorder can be both diagnosed and treated in individuals with primary mental retardation.
作者报告了5名患有严重精神发育迟滞的患者，他们有强烈的躁郁症症状，并且在一项为期三年的锂盐单盲安慰剂对照试验中症状显著减轻。疾病发作次数减少，所有主要疾病维度的症状都有所减轻。这些发现表明，原发性精神发育迟滞患者也可以诊断和治疗重度情感障碍。
