Hindle T H
Calif Med. 1972 Aug;117(2):7-11.
A double-blind study was carried out to determine the effectiveness of a muscle relaxant, carisoprodol, in the treatment of the low back syndrome, and to test whether this drug would produce any greater effect than an active sedative control. Forty-eight Mexican migrant farm laborers with acute lumbar strain and spasm were given either carisoprodol 350 mg, butabarbital 15 mg, or placebo, four times daily for four days, and then were rated on pertinent symptoms, the degree of limitation of motion (by an objective finger-to-floor test), and overall improvement. In the 43 patients who could be statistically analyzed, carisoprodol was shown to be significantly more effective than butabarbital or placebo in producing improvement of all factors rated. This result suggests that the effects of carisoprodol are not due solely to sedative action, but are also related to its muscle relaxant activity.
开展了一项双盲研究，以确定肌肉松弛剂卡立普多在治疗下背综合征方面的有效性，并测试该药物是否会比活性镇静对照产生更大的效果。48名患有急性腰部劳损和痉挛的墨西哥流动农场工人，每天服用350毫克卡立普多、15毫克布他比妥或安慰剂，每日4次，共4天，然后对相关症状、运动受限程度（通过客观的手指触地测试）和总体改善情况进行评分。在43名可进行统计分析的患者中，卡立普多在改善所有评分因素方面比布他比妥或安慰剂显著更有效。这一结果表明，卡立普多的作用并非仅仅归因于镇静作用，还与其肌肉松弛活性有关。
