静脉注射头孢拉定和头孢唑林治疗严重感染。
Intravenous use of cephradine and cefazolin against serious infections.
作者信息
Caloza D L, Semar R W, Bernfeld G E
出版信息
Antimicrob Agents Chemother. 1979 Jan;15(1):119-22. doi: 10.1128/AAC.15.1.119.
Abstract
The relative efficacy and safety of cephradine and cefazolin were compared in 180 patients with a variety of serious infections caused by susceptible organisms. The patients were randomly assigned to one of two groups of 90 patients each. Most patients received 2 to 4 g per day, administered by intravenous injection in four equally divided doses, for a minimum of 4 days. Based on the clinical and microbiological results, the two cephalosporins were found to be comparable in therapeutic effectiveness. Toxicity was not a problem with either drug.
摘要
在180例由敏感菌引起的各种严重感染患者中，对头孢拉定和头孢唑林的相对疗效和安全性进行了比较。患者被随机分为两组，每组90例。大多数患者每天接受2至4克药物治疗，通过静脉注射分四次等量给药，至少持续4天。根据临床和微生物学结果，发现这两种头孢菌素在治疗效果上相当。两种药物均未出现毒性问题。
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本文引用的文献
1
Antibiotic susceptibility testing by a standardized single disk method.采用标准化单纸片法进行抗生素敏感性试验。
Am J Clin Pathol. 1966 Apr;45(4):493-6.
2
A study in general practice of cephradine in respiratory tract infections.
Curr Med Res Opin. 1974;2(2):72-7. doi: 10.1185/03007997409114248.
3
Summary of symposium on cefazolin.
J Infect Dis. 1973 Oct;128:Suppl:S422-4. doi: 10.1093/infdis/128.supplement_2.s422.
4
Use of cephradine in respiratory tract infections.头孢拉定在呼吸道感染中的应用。
J Ir Med Assoc. 1973 Mar 24;Suppl:18-24.
5
Utilization of cephradine for suspension in paediatric infections.头孢拉定在儿科感染中的混悬剂应用。
J Ir Med Assoc. 1973 Mar 24;Suppl:31-3.
6
Clinical experience with oral cephradine.口服头孢拉定的临床经验。
J Ir Med Assoc. 1973 Mar 24;Suppl:25-8.
7
Cephradine--a summary of preclinical studies and clinical pharmacology.
J Ir Med Assoc. 1973 Mar 24;Suppl:1-12.
8
Drug therapy: The newer cephalosporins.
N Engl J Med. 1976 Jan 1;294(1):24-8. doi: 10.1056/NEJM197601012940106.
9
Treatment of urinary tract infections with cephradine.用头孢拉定治疗尿路感染。
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