鲍恩病和鳞状细胞癌。在一名银屑病患者经外用、全身及光化学疗法（PUVA）治疗后发生。

Bowen's disease and squamous cell carcinoma. Occurrence in a patient with psoriasis after topical, systemic, and PUVA therapy.

作者信息

Tam D W, Van Scott E J, Urbach F

出版信息

Arch Dermatol. 1979 Feb;115(2):203-4. doi: 10.1001/archderm.115.2.203.

DOI:10.1001/archderm.115.2.203

Abstract

Multiple lesions of Bowen's disease and squamous cell carcinoma on the penis and pubic areas developed in a 32-year-old patient with psoriasis who was undergoing treatment with psoralen and long-wave ultraviolet radiation (PUVA). A cumulative dose of more than 3,700 joules/sq cm of UVA had been administered over a three-year period. This case may be an early warning of possible carcinogenicity of PUVA therapy, alone or as part of sequential therapy with other agents.

摘要

一名32岁正在接受补骨脂素和长波紫外线辐射（PUVA）治疗的银屑病患者，阴茎和耻骨部位出现了多灶性鲍恩病和鳞状细胞癌。在三年时间里，累计给予的UVA剂量超过3700焦耳/平方厘米。该病例可能是PUVA治疗单独使用或作为与其他药物序贯治疗一部分时可能致癌性的早期警示。