• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Active centers of microsomal cytochrome P-450 determined with metyrapone by mutural depletion system kinetics.

作者信息

Roots I, Hildebrandt A G

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1973;277(1):39-52. doi: 10.1007/BF00498783.

DOI:10.1007/BF00498783
PMID:4267597
Abstract
摘要

相似文献

1
Active centers of microsomal cytochrome P-450 determined with metyrapone by mutural depletion system kinetics.采用甲吡酮通过相互消耗系统动力学测定微粒体细胞色素P-450的活性中心。
Naunyn Schmiedebergs Arch Pharmacol. 1973;277(1):39-52. doi: 10.1007/BF00498783.
2
Non-competitive and competitive inhibition of mixed function oxidase in rat liver microsomes by metyrapone.甲吡酮对大鼠肝微粒体中混合功能氧化酶的非竞争性和竞争性抑制作用。
Naunyn Schmiedebergs Arch Pharmacol. 1973;277(1):27-38. doi: 10.1007/BF00498782.
3
Determination of active centers of hepatic microsomal cytochrome P-450 by metyrapone, applying mutual depletion system kinetics.采用相互消耗系统动力学，通过甲吡酮测定肝微粒体细胞色素P-450的活性中心。
Drug Metab Dispos. 1973 Jan-Feb;1(1):194-8.
4
Influence of pyridine and some pyridine derivatives on spectral properties of reduced microsomes and on microsomal drug metabolizing activity.
Biochem Pharmacol. 1974 Apr 15;23(8):1319-29. doi: 10.1016/0006-2952(74)90334-7.
5
Nature of N-nitrosodimethylamine demethylase in hepatic microsomes of rats.大鼠肝微粒体中N-亚硝基二甲胺脱甲基酶的性质
Arch Toxicol. 1984 Nov;56(1):7-11. doi: 10.1007/BF00316344.
6
Complexes of cytochrome P450 with metyrapone. A convenient method for the quantitative analysis of phenobarbital-inducible cytochrome P450 in rat liver microsomes.细胞色素P450与美替拉酮的复合物。一种定量分析大鼠肝微粒体中苯巴比妥诱导的细胞色素P450的简便方法。
FEBS Lett. 1982 Nov 8;148(2):302-6. doi: 10.1016/0014-5793(82)80829-6.
7
Production of hydroxyl radicals and their role in the oxidation of ethanol by a reconstituted microsomal system containing cytochrome P-450 purified from phenobarbital-treated rats.由含有从苯巴比妥处理过的大鼠中纯化的细胞色素P-450的重组微粒体系统产生羟自由基及其在乙醇氧化中的作用。
Biochem Biophys Res Commun. 1979 Dec 14;91(3):747-54. doi: 10.1016/0006-291x(79)91943-0.
8
Limitations on the metyrapone assay for the major phenobarbital inducible form of cytochrome P-450.对主要由苯巴比妥诱导的细胞色素P - 450形式的美替拉酮测定法的局限性。
Biochem Biophys Res Commun. 1982 Apr 29;105(4):1322-6. doi: 10.1016/0006-291x(82)90931-7.
9
Pyridine nucleotide involvement in rat hepatic microsomal drug metabolism--IV. Inhibition of aminopyrine and ethylmorphine-N-demethylases by 2.6-dihydroxy-acetophenone.
Biochem Pharmacol. 1979 Apr 15;28(8):1421-5. doi: 10.1016/0006-2952(79)90446-5.
10
Effect of certain drugs and environmental agents on microsomal enzyme systems.某些药物和环境因素对微粒体酶系统的影响。
Sci Total Environ. 1972 Aug;1(2):181-95. doi: 10.1016/0048-9697(72)90005-8.

引用本文的文献

1
Non-competitive and competitive inhibition of mixed function oxidase in rat liver microsomes by metyrapone.甲吡酮对大鼠肝微粒体中混合功能氧化酶的非竞争性和竞争性抑制作用。
Naunyn Schmiedebergs Arch Pharmacol. 1973;277(1):27-38. doi: 10.1007/BF00498782.

本文引用的文献

1
THE MECHANISM OF ENZYME-INHIBITOR-SUBSTRATE REACTIONS : ILLUSTRATED BY THE CHOLINESTERASE-PHYSOSTIGMINE-ACETYLCHOLINE SYSTEM.酶-抑制剂-底物反应的机制：以胆碱酯酶-毒蕈碱-乙酰胆碱系统为例。
J Gen Physiol. 1944 Jul 20;27(6):529-80. doi: 10.1085/jgp.27.6.529.
2
ZONE BEHAVIOR OF ENZYMES : ILLUSTRATED BY THE EFFECT OF DISSOCIATION CONSTANT AND DILUTION ON THE SYSTEM CHOLINESTERASE-PHYSOSTIGMINE.酶的区域行为：以离解常数和稀释对胆碱酯酶-毒扁豆碱体系的影响为例。
J Gen Physiol. 1943 Jul 20;26(6):559-85. doi: 10.1085/jgp.26.6.559.
3
Determination of serum proteins by means of the biuret reaction.
通过双缩脲反应测定血清蛋白。
J Biol Chem. 1949 Feb;177(2):751-66.
4
THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.肝微粒体的一氧化碳结合色素。II. 增溶、纯化及性质
J Biol Chem. 1964 Jul;239:2379-85.
5
The colorimetric estimation of formaldehyde by means of the Hantzsch reaction.通过汉茨希反应对比色法测定甲醛。
Biochem J. 1953 Oct;55(3):416-21. doi: 10.1042/bj0550416.
6
The determination of enzyme inhibitor constants.酶抑制剂常数的测定
Biochem J. 1953 Aug;55(1):170-1. doi: 10.1042/bj0550170.
7
[Studies on cholinesterase. 7. Determination of the molar concentration of pseudo-cholinesterase in serum].[胆碱酯酶研究。7. 血清中假性胆碱酯酶摩尔浓度的测定]
Biochem J. 1952 Jun;51(3):303-11. doi: 10.1042/bj0510303.
8
Spectrophotometric studies of interactions between various substrates in their binding to microsomal cytochrome P-450.各种底物与微粒体细胞色素P-450结合时相互作用的分光光度研究。
Biochem Biophys Res Commun. 1969 Aug 22;36(5):789-94. doi: 10.1016/0006-291x(69)90678-0.
9
Two adrenal gland cytochrome P-450 entities evidenced by metyrapone-induced spectra.美替拉酮诱导光谱证实的两种肾上腺细胞色素P-450实体。
Biochim Biophys Acta. 1970 Nov 3;223(1):105-14. doi: 10.1016/0005-2728(70)90135-0.
10
Metyrapone interaction with hepatic microsomal cytochrome P-450 from rats treated with phenobarbital.甲吡酮与经苯巴比妥处理的大鼠肝脏微粒体细胞色素P-450的相互作用。
Biochem Biophys Res Commun. 1969 Oct 22;37(3):477-85. doi: 10.1016/0006-291x(69)90940-1.