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Metyrapone interaction with hepatic microsomal cytochrome P-450 from rats treated with phenobarbital.

作者信息

Hildebrandt A G, Leibman K C, Estabrook R W

出版信息

Biochem Biophys Res Commun. 1969 Oct 22;37(3):477-85. doi: 10.1016/0006-291x(69)90940-1.

DOI:10.1016/0006-291x(69)90940-1
PMID:5349284
Abstract
摘要

相似文献

1
Metyrapone interaction with hepatic microsomal cytochrome P-450 from rats treated with phenobarbital.甲吡酮与经苯巴比妥处理的大鼠肝脏微粒体细胞色素P-450的相互作用。
Biochem Biophys Res Commun. 1969 Oct 22;37(3):477-85. doi: 10.1016/0006-291x(69)90940-1.
2
Complexes of cytochrome P450 with metyrapone. A convenient method for the quantitative analysis of phenobarbital-inducible cytochrome P450 in rat liver microsomes.细胞色素P450与美替拉酮的复合物。一种定量分析大鼠肝微粒体中苯巴比妥诱导的细胞色素P450的简便方法。
FEBS Lett. 1982 Nov 8;148(2):302-6. doi: 10.1016/0014-5793(82)80829-6.
3
Metyrapone - reduced cytochrome P-450 complex: a specific method for the determination of the phenobarbital inducible form of rat hepatic microsomal cytochrome P-450.甲吡酮还原型细胞色素P - 450复合物：一种测定大鼠肝微粒体细胞色素P - 450苯巴比妥诱导型的特定方法。
Biochem Biophys Res Commun. 1980 Apr 14;93(3):776-81. doi: 10.1016/0006-291x(80)91144-4.
4
Factors influencing the inhibitory effect of carbon monoxide on cytochrome P-450-catalyzed mixed function oxidation reactions.
Ann N Y Acad Sci. 1970 Oct 5;174(1):218-32. doi: 10.1111/j.1749-6632.1970.tb49788.x.
5
Limitations on the metyrapone assay for the major phenobarbital inducible form of cytochrome P-450.对主要由苯巴比妥诱导的细胞色素P - 450形式的美替拉酮测定法的局限性。
Biochem Biophys Res Commun. 1982 Apr 29;105(4):1322-6. doi: 10.1016/0006-291x(82)90931-7.
6
Association of the Ah locus with specific changes in metyrapone and ethylisocyanide binding to mouse liver microsomes.Ah基因座与甲吡酮及乙基异氰化物与小鼠肝脏微粒体结合的特定变化之间的关联。
J Biol Chem. 1976 Sep 10;251(17):5397-407.
7
Proceedings: Kinetics of the binding of carbon monoxide and oxygen to microsomal cytochrome P450 and the influence of substrates.
Naunyn Schmiedebergs Arch Pharmacol. 1974;282(Suppl):suppl 282:R81.
8
Influence of pyridine and some pyridine derivatives on spectral properties of reduced microsomes and on microsomal drug metabolizing activity.
Biochem Pharmacol. 1974 Apr 15;23(8):1319-29. doi: 10.1016/0006-2952(74)90334-7.
9
The binding of metyrapone to cytochrome P-450 and its inhibitory action on microsomal hepatic mixed function oxidation reactions.甲吡酮与细胞色素P - 450的结合及其对肝微粒体混合功能氧化反应的抑制作用。
Biochem Soc Symp. 1972;34:79-102.
10
Proceedings: Evidence for oxidative metabolism of metyrapone in rat liver microsomes.
Naunyn Schmiedebergs Arch Pharmacol. 1974;282(Suppl):suppl 282:R44.

引用本文的文献

1
Evidence that ligand formation is a mechanism underlying the maintenance of cytochrome P-450 in rat liver cell culture. Potent maintenance by metyrapone.配体形成是大鼠肝细胞培养中细胞色素P - 450维持机制的证据。美替拉酮具有强大的维持作用。
Biochem J. 1980 Jun 15;188(3):937-9. doi: 10.1042/bj1880937.
2
Studies on the substrate specificity and inducibility of cytochrome P-450meg.细胞色素P-450meg的底物特异性和诱导性研究。
Biochem J. 1981 Jun 15;196(3):781-6. doi: 10.1042/bj1960781.
3
The role of 5-aminolaevulinate synthase, haem oxygenase and ligand formation in the mechanism of maintenance of cytochrome P-450 concentration in hepatocyte culture.
5-氨基乙酰丙酸合成酶、血红素加氧酶及配体形成在维持肝细胞培养物中细胞色素P-450浓度机制中的作用
Biochem J. 1983 Mar 15;210(3):855-7. doi: 10.1042/bj2100855.
4
The binding of metyrapone to cytochrome P-450 and its inhibitory action on liver microsomal mixed-function oxidase reactions.甲吡酮与细胞色素P - 450的结合及其对肝微粒体混合功能氧化酶反应的抑制作用。
Biochem J. 1971 Nov;125(2):6P-8P. doi: 10.1042/bj1250006p.
5
Non-competitive and competitive inhibition of mixed function oxidase in rat liver microsomes by metyrapone.甲吡酮对大鼠肝微粒体中混合功能氧化酶的非竞争性和竞争性抑制作用。
Naunyn Schmiedebergs Arch Pharmacol. 1973;277(1):27-38. doi: 10.1007/BF00498782.
6
Action of metyrapone on the redox state of free nicotinamide-adenine dinucleotide and on oxygen consumption of perfused rat livers and isolated mitochondria.甲吡酮对游离烟酰胺腺嘌呤二核苷酸氧化还原状态以及对灌注大鼠肝脏和分离线粒体氧消耗的作用。
Naunyn Schmiedebergs Arch Pharmakol. 1971;268(1):1-16. doi: 10.1007/BF00997168.
7
The mechanism of halothane binding to microsomal cytochrome P450.
Naunyn Schmiedebergs Arch Pharmacol. 1974;285(4):315-24. doi: 10.1007/BF00501461.
8
Active centers of microsomal cytochrome P-450 determined with metyrapone by mutural depletion system kinetics.采用甲吡酮通过相互消耗系统动力学测定微粒体细胞色素P-450的活性中心。
Naunyn Schmiedebergs Arch Pharmacol. 1973;277(1):39-52. doi: 10.1007/BF00498783.
9
Species of cytochrome P-450 in rat liver microsomes with different stereoselectivity for the binding and monooxygenation of (+)- and (-)-methylphenobarbital.大鼠肝微粒体中对（+）-和（-）-甲基苯巴比妥的结合及单加氧作用具有不同立体选择性的细胞色素P-450种类。
Naunyn Schmiedebergs Arch Pharmakol. 1971;270(1):41-55. doi: 10.1007/BF00997298.
10
Experiments on the metyrapone reducing microsomal enzyme system.
Naunyn Schmiedebergs Arch Pharmakol. 1970;266(1):61-74. doi: 10.1007/BF00997783.