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1
Evidence for the existence of isoenzymes of glycerol phosphate acyltransferase.磷酸甘油酰基转移酶同工酶存在的证据。
Biochem J. 1979 Jan 1;177(1):283-8. doi: 10.1042/bj1770283.
2
Regulation by noradrenaline of the mitochondrial and microsomal forms of glycerol phosphate acyltransferase in rat adipocytes.去甲肾上腺素对大鼠脂肪细胞中线粒体和微粒体形式的甘油磷酸酰基转移酶的调节作用。
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3
A study of the glycerol phosphate acyltransferase and dihydroxyacetone phosphate acyltransferase activities in rat liver mitochondrial and microsomal fractions. Relative distribution in parenchymal and non-parenchymal cells, effects of N-ethylmaleimide, palmitoyl-coenzyme A concentration, starvation, adrenalectomy and anti-insulin serum treatment.大鼠肝脏线粒体和微粒体组分中甘油磷酸酰基转移酶和磷酸二羟丙酮酰基转移酶活性的研究。在实质细胞和非实质细胞中的相对分布、N-乙基马来酰亚胺的影响、棕榈酰辅酶A浓度、饥饿、肾上腺切除术及抗胰岛素血清处理的影响
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4
A trypsin-sensitive, heat-labile, N-ethylmaleimide-sensitive factor in adipocyte post-microsomal supernatant which affects the assay of adipocyte glycerol phosphate acyltransferase activities.脂肪细胞微粒体后上清液中一种对胰蛋白酶敏感、对热不稳定、对N - 乙基马来酰亚胺敏感的因子，它会影响脂肪细胞甘油磷酸酰基转移酶活性的测定。
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5
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6
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7
Triacylglycerol synthesis in isolated fat cells. Evidence that the sn-glycerol-3-phosphate and dihydroxyacetone phosphate acyltransferase activities are dual catalytic functions of a single microsomal enzyme.分离脂肪细胞中的三酰甘油合成。证明sn-甘油-3-磷酸和磷酸二羟丙酮酰基转移酶活性是单一微粒体酶的双重催化功能。
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8
Rat liver dihydroxyacetone-phosphate acyltransferases and their contribution to glycerolipid synthesis.大鼠肝脏磷酸二羟丙酮酰基转移酶及其在甘油脂质合成中的作用。
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9
A genuine acyl donor activity of oleyl-CoA for mitochondrial glycerophosphate acyltransferase.油酰辅酶A对线粒体甘油磷酸酰基转移酶的真正酰基供体活性。
FEBS Lett. 1982 Aug 23;145(2):281-4. doi: 10.1016/0014-5793(82)80183-x.
10
Studies of rat adipose-tissue microsomal glycerol phosphate acyltransferase.大鼠脂肪组织微粒体甘油磷酸酰基转移酶的研究。
Biochem J. 1984 Nov 15;224(1):101-8. doi: 10.1042/bj2240101.

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Purification and characterization of thiol-reagent-sensitive glycerol-3-phosphate acyltransferase from the membrane fraction of an oleaginous fungus.从产油真菌膜组分中纯化及鉴定对硫醇试剂敏感的甘油-3-磷酸酰基转移酶
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6
Role of glycerol 3-phosphate and glycerophosphate acyltransferase in the nutritional control of hepatic triacylglycerol synthesis.3-磷酸甘油和甘油磷酸酰基转移酶在肝脏三酰甘油合成营养调控中的作用
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7
Studies of rat adipose-tissue microsomal glycerol phosphate acyltransferase.大鼠脂肪组织微粒体甘油磷酸酰基转移酶的研究。
Biochem J. 1984 Nov 15;224(1):101-8. doi: 10.1042/bj2240101.
8
Regulation by noradrenaline of the mitochondrial and microsomal forms of glycerol phosphate acyltransferase in rat adipocytes.去甲肾上腺素对大鼠脂肪细胞中线粒体和微粒体形式的甘油磷酸酰基转移酶的调节作用。
Biochem J. 1983 Jul 15;214(1):235-46. doi: 10.1042/bj2140235.
9
Effects of chronic modification of dietary fat and carbohydrate in rats.大鼠饮食中脂肪和碳水化合物长期改变的影响。
Biochem J. 1981 Nov 15;200(2):265-73. doi: 10.1042/bj2000265.
10
Subcellular distribution and some properties of N-ethylmaleimide-sensitive and-insensitive forms of glycerol phosphate acyltransferase in rat adipocytes.大鼠脂肪细胞中对N-乙基马来酰亚胺敏感和不敏感形式的甘油磷酸酰基转移酶的亚细胞分布及某些特性
Biochem J. 1980 Jul 15;190(1):183-9. doi: 10.1042/bj1900183.

本文引用的文献

1
METABOLISM OF GLYCEROLIPIDS. VI. SPECIFICITIES OF ACYL COENZYME A: PHOSPHOLIPID ACYLTRANSFERASES.甘油脂质的代谢。VI. 酰基辅酶A：磷脂酰基转移酶的特异性。
J Biol Chem. 1965 May;240:1905-11.
2
Tissue fractionation studies. 6. Intracellular distribution patterns of enzymes in rat-liver tissue.组织分级分离研究。6. 大鼠肝脏组织中酶的细胞内分布模式。
Biochem J. 1955 Aug;60(4):604-17. doi: 10.1042/bj0600604.
3
Enzymatic esterification of alpha-glycerophosphate by long chain fatty acids.长链脂肪酸对α-甘油磷酸的酶促酯化作用。
J Biol Chem. 1953 Sep;204(1):345-57.
4
Phospholipid synthesis in rat liver mitochondria.大鼠肝脏线粒体中的磷脂合成
Biochim Biophys Acta. 1969 Jul 29;187(1):73-84. doi: 10.1016/0005-2760(69)90134-9.
5
Biosynthesis of acyl dihydroxyacetone phosphate in guinea pig liver mitochondria.豚鼠肝脏线粒体中酰基二羟基丙酮磷酸的生物合成
J Biol Chem. 1968 Jun 25;243(12):3458-65.
6
The separation and properties of two forms of carnitine palmitoyltransferase from ox liver mitochondria.牛肝线粒体中两种形式的肉碱棕榈酰转移酶的分离及特性
Biochem Biophys Res Commun. 1971 Mar 5;42(5):912-8. doi: 10.1016/0006-291x(71)90517-1.
7
The acylation of glycerophosphate in rat liver. A new assay procedure for glycerophosphate acylation, studies on its subcellular and submitochondrial localization and determination of the reaction products.
Biochim Biophys Acta. 1970 Jun 9;210(1):92-104. doi: 10.1016/0005-2760(70)90065-2.
8
Phosphatidate synthesis by sn-glycerol-3-phosphate acyltransferase in pigeon liver particles.
Biochim Biophys Acta. 1970 Feb 10;202(1):129-40. doi: 10.1016/0005-2760(70)90224-9.
9
A substrate- and position-specific acylation of sn-glycerol 3-phosphate by rat liver mitochondria.大鼠肝脏线粒体对sn-甘油-3-磷酸的底物及位置特异性酰化作用。
J Biol Chem. 1972 Nov 10;247(21):6884-94.
10
The mitochondrial acylation of glycerophosphate in rat liver: fatty acid and positional specificity.大鼠肝脏中甘油磷酸的线粒体酰化作用：脂肪酸及位置特异性
Biochim Biophys Acta. 1972 May 23;270(1):23-31. doi: 10.1016/0005-2760(72)90173-7.

磷酸甘油酰基转移酶同工酶存在的证据。

Evidence for the existence of isoenzymes of glycerol phosphate acyltransferase.

作者信息

Nimmo H G

出版信息

Biochem J. 1979 Jan 1;177(1):283-8. doi: 10.1042/bj1770283.

DOI:10.1042/bj1770283
PMID:426773
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1186367/
Abstract

Subcellular-fractionation studies confirmed previous findings that rat liver glycerol phosphate acyltransferase was located in both mitochondria and the microsomal fraction. Studies of the two activities revealed several differences between them. The mitochondrial enzyme had a lower Km for sn-glycerol 3-phosphate and was more resistant to heat inactivation than was the microsomal enzyme. Some preparations of the mitochondrial enzyme were inhibited by high concentrations of glycerol phosphate. The mitochondrial enzyme was not inactivated by thiol-group reagents, whereas the microsomal enzyme was very rapidly inactivated by these compounds. However, the microsomal enzyme could be specifically protected against this inactivation by low concentrations of palmitoyl-CoA. The results indicate the existence of distinct isoenzymes of glycerol phosphate acyltransferase with different intracellular locations.

摘要

亚细胞分级分离研究证实了先前的发现，即大鼠肝脏甘油磷酸酰基转移酶存在于线粒体和微粒体部分。对这两种活性的研究揭示了它们之间的几个差异。线粒体酶对sn-甘油3-磷酸的Km值较低，并且比微粒体酶更耐热失活。线粒体酶的一些制剂会受到高浓度甘油磷酸的抑制。线粒体酶不会被巯基试剂灭活，而微粒体酶会被这些化合物非常迅速地灭活。然而，低浓度的棕榈酰辅酶A可以特异性地保护微粒体酶免受这种灭活。结果表明存在具有不同细胞内定位的甘油磷酸酰基转移酶的不同同工酶。