Berman L, Stilmant M, Hayes J A
Am J Pathol. 1976 Jul;84(1):139-48.
In the Syrian hamster, administration of the drug streptozotocin was associated with an increased incidence and severity of renal amyloidosis. Some of the more severely affected animals showed a frankly nephrotic picture. Although some of the diseased animals showed decreased levels of serum albumin, no other definite changes in serum proteins were noted, nor was there any evidence of glomerular immunoglobulin or immune complex deposition. None of the lesions previously found after administration of streptozotocin in the Chinese hamster were encountered.
在叙利亚仓鼠中，注射链脲佐菌素与肾淀粉样变性的发病率和严重程度增加有关。一些受影响更严重的动物呈现出明显的肾病症状。尽管一些患病动物的血清白蛋白水平降低，但未发现血清蛋白有其他明确变化，也没有肾小球免疫球蛋白或免疫复合物沉积的证据。未发现先前在中国仓鼠注射链脲佐菌素后出现的任何病变。
