混合淋巴细胞培养中B细胞和T细胞的增殖
Proliferation of B and T cells in mixed lymphocyte cultures.
作者信息
Andersson L C, Nordling S, Häyry P
出版信息
J Exp Med. 1973 Jul 1;138(1):324-9. doi: 10.1084/jem.138.1.324.
Abstract
Electrophoretically fractionated CBA/Ca spleen T cells alone respond to allogeneic cells in one-way MLC and to PHA. They do not respond to E. coli LPS. B cells alone do not respond to allogeneic cells nor to PHA, but do respond to LPS. When karyotypically distinguishable syngeneic mixtures of T and B lymphocytes are stimulated with allogeneic cells, at the most 5% of mitoses on 5-9th culture day are of B cell origin. This indicates that B cells are not substantially recruited to proliferate in the MLC.
摘要
经电泳分离的CBA/Ca脾T细胞单独存在时，能在单向混合淋巴细胞培养中对同种异体细胞作出反应，也能对PHA作出反应。它们对大肠杆菌脂多糖无反应。单独的B细胞对同种异体细胞和PHA均无反应，但对脂多糖有反应。当用同种异体细胞刺激T和B淋巴细胞的核型可区分的同基因混合物时，在培养第5 - 9天，最多5%的有丝分裂细胞起源于B细胞。这表明在混合淋巴细胞培养中，B细胞并没有大量被募集来增殖。
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