小鼠外周淋巴组织中含θ细胞的胸腺依赖性
Thymus dependence of theta-bearing cells in the peripheral lymphoid tissues of mice.
作者信息
Raff M C, Wortis H H
出版信息
Immunology. 1970 Jun;18(6):931-42.
Abstract
In mice thymectomized as newborns, thymectomized as adults and irradiated, and in mice with congenital absence of the thymus, there is a marked reduction in the number of θ-bearing lymphocytes in the lymph nodes and spleen. This suggests that θ is present on those lymphocytes which are thymus-derived. Using Cr and dye exclusion cytotoxic testing, approximately 65–85 per cent of lymph node and thoracic duct lymphocytes and 30–50 per cent of spleen lymphocytes were found to have θ on their surface.
摘要
在新生时进行胸腺切除、成年时进行胸腺切除并接受辐射的小鼠，以及先天性无胸腺的小鼠中，淋巴结和脾脏中带有θ的淋巴细胞数量显著减少。这表明θ存在于那些源自胸腺的淋巴细胞上。通过铬释放和染料排除细胞毒性测试发现，大约65%-85%的淋巴结和胸导管淋巴细胞以及30%-50%的脾脏淋巴细胞表面带有θ。
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