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Cytochrome P450 product complexes and glutathione consumption produced in isolated hepatocytes by norbenzphetamine and its N-oxidized congeners.

作者信息

Hirata M, Lindeke B, Orrenius S

出版信息

Biochem Pharmacol. 1979;28(4):479-84. doi: 10.1016/0006-2952(79)90239-9.

DOI:10.1016/0006-2952(79)90239-9
PMID:426867
Abstract
摘要

相似文献

1
Cytochrome P450 product complexes and glutathione consumption produced in isolated hepatocytes by norbenzphetamine and its N-oxidized congeners.去甲苄非他明及其N-氧化同系物在离体肝细胞中产生的细胞色素P450产物复合物和谷胱甘肽消耗。
Biochem Pharmacol. 1979;28(4):479-84. doi: 10.1016/0006-2952(79)90239-9.
2
Interaction of constitutive and phenobarbital-induced cytochrome P-450 isozymes during the sequential oxidation of benzphetamine. Explanation for the difference in benzphetamine-induced hydrogen peroxide production and 455-nm complex formation in microsomes from untreated and phenobarbital-treated rats.苯丙胺连续氧化过程中组成型和苯巴比妥诱导的细胞色素P-450同工酶的相互作用。对未处理和苯巴比妥处理大鼠微粒体中苯丙胺诱导的过氧化氢产生和455纳米复合物形成差异的解释。
Mol Pharmacol. 1983 May;23(3):748-57.
3
Correlations between spin equilibrium shift, reduction rate, and N-demethylation activity in liver microsomal cytochrome P-450 and a series of benzphetamine analogues as substrates.肝脏微粒体细胞色素P-450中自旋平衡移动、还原速率和N-去甲基化活性与一系列作为底物的苄非他明类似物之间的相关性。
Biochem Pharmacol. 1983 Jun 1;32(11):1683-8. doi: 10.1016/0006-2952(83)90109-0.
4
Spin state control of cytochrome P-450 reduction and catalytic activity in a reconstituted P-450 LM2 system as induced by a series of benzphetamine analogues.
Chem Biol Interact. 1985 Jul;54(2):127-41. doi: 10.1016/s0009-2797(85)80158-7.
5
NADPH-dependent reduction of cytochrome P-450 in liver microsomes from vitamin C-deficient guinea pigs: effect of benzphetamine.维生素C缺乏的豚鼠肝脏微粒体中细胞色素P-450的NADPH依赖性还原：苄非他明的作用
J Nutr. 1982 Sep;112(9):1796-800. doi: 10.1093/jn/112.9.1796.
6
Cytochrome P-450-product complexes produced by amphetamine derivatives: a comparative study with isolated liver microsomes and hepatocytes.苯丙胺衍生物产生的细胞色素P-450-产物复合物：与分离的肝微粒体和肝细胞的比较研究
Acta Pharmacol Toxicol (Copenh). 1977 Aug;41(2):177-89. doi: 10.1111/j.1600-0773.1977.tb02137.x.
7
Comparisons of the formation of cytochrome P-450 complexes absorbing at 455 nm in rabbit and rat microsomes.兔和大鼠微粒体中吸收波长为455nm的细胞色素P-450复合物形成的比较。
Biochem Pharmacol. 1975 Apr 15;24(8):835-8. doi: 10.1016/0006-2952(75)90150-1.
8
Studies of the metabolism of diethyl p-nitrophenyl phosphorothionate (parathion) and benzphetamine using an apparently homogeneous preparation of rat liver cytochrome P-450: effect of a cytochrome P-450 antibody preparation.使用明显均一的大鼠肝脏细胞色素P - 450制剂对硫代磷酸O,O - 二乙基 - O - 对硝基苯基酯（对硫磷）和苄非他明代谢的研究：细胞色素P - 450抗体制剂的作用
Mol Pharmacol. 1976 Nov;12(6):921-32.
9
Detoxification reactions in isolated hepatocytes. Role of glutathione peroxidase, catalase, and formaldehyde dehydrogenase in reactions relating to N-demethylation by the cytochrome P-450 system.
J Biol Chem. 1978 Sep 10;253(17):6031-7.
10
Production of hydroxyl radicals and their role in the oxidation of ethanol by a reconstituted microsomal system containing cytochrome P-450 purified from phenobarbital-treated rats.由含有从苯巴比妥处理过的大鼠中纯化的细胞色素P-450的重组微粒体系统产生羟自由基及其在乙醇氧化中的作用。
Biochem Biophys Res Commun. 1979 Dec 14;91(3):747-54. doi: 10.1016/0006-291x(79)91943-0.

引用本文的文献

1
The nitrosoamphetamine metabolite is accommodated in the active site of human hemoglobin: Spectroscopy and crystal structure.亚硝基苯丙胺代谢物可容纳于人血红蛋白的活性部位：光谱和晶体结构。
J Inorg Biochem. 2020 Dec;213:111262. doi: 10.1016/j.jinorgbio.2020.111262. Epub 2020 Sep 29.
2
Cytochrome P-450 metabolic-intermediate complex formation with a series of diphenhydramine analogues.细胞色素P-450与一系列苯海拉明类似物形成代谢中间复合物。
Agents Actions. 1990 Apr;30(1-2):161-5. doi: 10.1007/BF01969027.