Warren J, Sacksteder M R, Thuning C A
Arthritis Rheum. 1979 Apr;22(4):334-9. doi: 10.1002/art.1780220404.
Development of adjuvant disease in the rat is suppressed if hyperbaric oxygen is administered within one day after the inoculation of an oil suspension of Mycobacterium tuberculosis and continued for 16 to 17 days. Although 10 to 40% of the rodents developed mild arthritis after discontinuance of therapy, most remained symptom-free for at least 50 days. Oxygen administered after arthritis is advanced still exerted a significant curative effect. Possible mechanisms underlying the therapeutic action of oxygen are discussed.
如果在接种结核分枝杆菌油悬液后一天内给予高压氧并持续16至17天，大鼠佐剂病的发展会受到抑制。尽管在停止治疗后10%至40%的啮齿动物出现了轻度关节炎，但大多数至少50天内无症状。在关节炎进展后给予氧气仍有显著疗效。文中讨论了氧气治疗作用的潜在机制。
