Wardle E N, Floyd M
Br Med J. 1973 Aug 4;3(5874):255-7. doi: 10.1136/bmj.3.5874.255.
Three patients with bacterial endocarditis who developed renal failure have been studied by means of a radiofibrinogen catabolism study. Two were studied at the time of bacteraemia and one during the subsequent "immunological phase" of circulating immune complexes. Accelerated fibrinogen catabolism was found in all cases. Intravascular coagulation may be an important factor in the pathogenesis of proliferative glomerulonephritis in such cases.
通过放射性纤维蛋白原分解代谢研究对3例患细菌性心内膜炎并出现肾衰竭的患者进行了研究。2例在菌血症期进行了研究,1例在随后循环免疫复合物的“免疫期”进行了研究。所有病例均发现纤维蛋白原分解代谢加速。在这类病例中,血管内凝血可能是增殖性肾小球肾炎发病机制中的一个重要因素。