传统型和缓释型氧烯洛尔在空腹和非空腹个体中的生物利用度。
Bioavailability of conventional and slow-release oxprenolol in fasted and nonfasted individuals.
作者信息
Dawes C P, Kendall M J, Welling P G
出版信息
Br J Clin Pharmacol. 1979 Mar;7(3):299-302. doi: 10.1111/j.1365-2125.1979.tb00936.x.
Abstract
1 The influence of food and plasma levels of oxprenolol was examined in healthy female volunteers using both conventional and slow-release formulations. 2 There were no significant trends in plasma drug profiles due to food with either formulation. Elimination half-lives were longer after food with conventional tablets, presumably due to continued absorption. The opposite effect was seen with slow-release tablets. 3 Slow-release oxprenolol is, under the conditions of this study, a reliable and convenient dosage form, providing similar plasma-drug profiles in fasted and nonfasted individuals.
摘要
1 在健康女性志愿者中，使用常规制剂和缓释制剂研究了食物和氧烯洛尔血浆水平的影响。2 两种制剂在进食后血浆药物曲线均无显著变化趋势。常规片剂进食后消除半衰期延长，可能是由于持续吸收。而缓释片剂则出现相反的效果。3 在本研究条件下，缓释氧烯洛尔是一种可靠且方便的剂型，在禁食和非禁食个体中提供相似的血浆药物曲线。
相似文献
1
Bioavailability of conventional and slow-release oxprenolol in fasted and nonfasted individuals.传统型和缓释型氧烯洛尔在空腹和非空腹个体中的生物利用度。
Br J Clin Pharmacol. 1979 Mar;7(3):299-302. doi: 10.1111/j.1365-2125.1979.tb00936.x.
2
Absorption and excretion of rapid and slow release oxprenolol and their effects on heart rate and blood pressure during exercise.速释和缓释氧烯洛尔的吸收与排泄及其对运动时心率和血压的影响。
Br J Clin Pharmacol. 1979 Jun;7(6):545-9. doi: 10.1111/j.1365-2125.1979.tb04640.x.
3
A multiple dose comparative study of the pharmacodynamic and pharmacokinetic behaviour of polymer-matrix and Oros dosage forms of oxprenolol in healthy volunteers.在健康志愿者中进行的氧烯洛尔聚合物基质剂型和渗透泵控释剂型的药效学及药代动力学行为的多剂量对比研究。
Br J Clin Pharmacol. 1985;19 Suppl 2(Suppl 2):177S-184S. doi: 10.1111/j.1365-2125.1985.tb02759.x.
4
Relative bioavailability of different oral sustained release oxprenolol tablets.不同口服缓释氧烯洛尔片的相对生物利用度。
Eur J Drug Metab Pharmacokinet. 1998 Apr-Jun;23(2):178-84. doi: 10.1007/BF03189336.
5
Single-dose pharmacokinetic and pharmacodynamic comparison of polymer-matrix (Slow Trasicor) and Oros dosage forms of oxprenolol in healthy volunteers.健康志愿者中氧烯洛尔聚合物基质剂型（Slow Trasicor）和渗透泵控释剂型的单剂量药代动力学和药效学比较。
Br J Clin Pharmacol. 1985;19 Suppl 2(Suppl 2):171S-175S. doi: 10.1111/j.1365-2125.1985.tb02758.x.
6
Influence of food intake on plasma oxprenolol concentrations following oral administration of conventional and Oros preparations.食物摄入对口服常规制剂和渗透泵控释制剂后血浆氧烯洛尔浓度的影响。
Br J Clin Pharmacol. 1985;19 Suppl 2(Suppl 2):191S-195S. doi: 10.1111/j.1365-2125.1985.tb02761.x.
7
Pharmacokinetic investigation of the absorption of oxprenolol from Oros delivery systems in healthy volunteers: comparison of in vivo and in vitro drug release.氧烯洛尔从渗透泵控释系统在健康志愿者体内吸收的药代动力学研究：体内与体外药物释放的比较
Br J Clin Pharmacol. 1985;19 Suppl 2(Suppl 2):163S-169S. doi: 10.1111/j.1365-2125.1985.tb02757.x.
8
A comparison of slow release with conventional oxprenolol: plasma concentrations and clinical effects.缓释氧烯洛尔与传统氧烯洛尔的比较：血浆浓度及临床效果
Br J Clin Pharmacol. 1976 Jun;3(3):439-43. doi: 10.1111/j.1365-2125.1976.tb00619.x.
9
Comparison of pharmacokinetic profiles of single and multiple doses of a slow release Oros oxprenolol delivery system in young normotensive and elderly hypertensive subjects.单剂量和多剂量缓释Oros氧烯洛尔给药系统在年轻血压正常者和老年高血压患者中药代动力学特征的比较。
Br J Clin Pharmacol. 1986 Apr;21(4):371-6. doi: 10.1111/j.1365-2125.1986.tb05209.x.
10
Reproducibility of oxprenolol plasma concentrations in young female volunteers following oral administration of an oxprenolol Oros dosage form.口服氧烯洛尔渗透泵控释片剂型后年轻女性志愿者体内氧烯洛尔血药浓度的重现性。
Br J Clin Pharmacol. 1985;19 Suppl 2(Suppl 2):185S-190S. doi: 10.1111/j.1365-2125.1985.tb02760.x.
引用本文的文献
1
Extracorporeal treatment for poisoning to beta-adrenergic antagonists: systematic review and recommendations from the EXTRIP workgroup.体外治疗β-肾上腺素能拮抗剂中毒：EXTRIP 工作组的系统评价和建议。
Crit Care. 2021 Jun 10;25(1):201. doi: 10.1186/s13054-021-03585-7.
2
Comparison of the activity and plasma levels of oxprenolol, slow release oxprenolol, long acting propranolol and sotalol.氧烯洛尔、缓释氧烯洛尔、长效普萘洛尔和索他洛尔的活性及血药浓度比较。
Eur J Clin Pharmacol. 1980 Jun;17(6):419-24. doi: 10.1007/BF00570158.
3
Effect of food on the absorption of hydralazine in man.食物对人体中肼屈嗪吸收的影响。
Eur J Clin Pharmacol. 1981;20(1):53-8. doi: 10.1007/BF00554667.
4
Interactions affecting drug absorption.影响药物吸收的相互作用。
Clin Pharmacokinet. 1984 Sep-Oct;9(5):404-34. doi: 10.2165/00003088-198409050-00002.
5
Variability of beta-blocker pharmacokinetics in young volunteers.年轻志愿者中β受体阻滞剂药代动力学的变异性
Eur J Clin Pharmacol. 1982;23(1):37-42. doi: 10.1007/BF01061375.
6
Influence of food intake on plasma oxprenolol concentrations following oral administration of conventional and Oros preparations.食物摄入对口服常规制剂和渗透泵控释制剂后血浆氧烯洛尔浓度的影响。
Br J Clin Pharmacol. 1985;19 Suppl 2(Suppl 2):191S-195S. doi: 10.1111/j.1365-2125.1985.tb02761.x.
7
Jejunal and ileal absorption of oxprenolol in man: influence of nutrients and digestive secretions on jejunal absorption and systemic availability.人空肠和回肠对氧烯洛尔的吸收：营养素和消化液对空肠吸收及全身可用性的影响。
Br J Clin Pharmacol. 1987 Sep;24(3):335-41. doi: 10.1111/j.1365-2125.1987.tb03178.x.
本文引用的文献
1
Comparison of antibacterial activity in the sera of subjects ingesting propionyl erythromycin lauryl sulfate and erythromycin ethyl carbonate.
Antibiotic Med Clin Ther (New York). 1960 May;7:320-6.
2
An evaluation of erythromycin stearate and propionyl erythromycin in normal and hospitalized subjects.对硬脂酸红霉素和丙酰红霉素在正常受试者及住院患者中的评估。
Antibiotic Med Clin Ther (New York). 1960 Feb;7:91-6.
3
Absorption following oral administration of erythromycin.口服红霉素后的吸收情况。
J Am Med Assoc. 1953 Mar 7;151(10):805-10.
4
Plasma propranolol levels in adults with observations in four children.成人血浆普萘洛尔水平及对四名儿童的观察结果
Clin Pharmacol Ther. 1970 Jan-Feb;11(1):112-20. doi: 10.1002/cpt1970111112.
5
Plasma metoprolol concentrations in young, old and hypertensive subjects.年轻、老年和高血压受试者的血浆美托洛尔浓度。
Br J Clin Pharmacol. 1977 Aug;4(4):497-9.
6
Enhancement of the bioavailability of propranolol and metoprolol by food.食物对普萘洛尔和美托洛尔生物利用度的增强作用。
Clin Pharmacol Ther. 1977 Jul;22(1):108-12. doi: 10.1002/cpt1977221108.
7
A comparison of slow release with conventional oxprenolol: plasma concentrations and clinical effects.缓释氧烯洛尔与传统氧烯洛尔的比较：血浆浓度及临床效果
Br J Clin Pharmacol. 1976 Jun;3(3):439-43. doi: 10.1111/j.1365-2125.1976.tb00619.x.
8
Influence of food and diet on gastrointestinal drug absorption: a review.食物和饮食对胃肠道药物吸收的影响：综述
J Pharmacokinet Biopharm. 1977 Aug;5(4):291-334. doi: 10.1007/BF01061694.
9
Pharmacokinetics of oxprenolol in normal subjects.氧烯洛尔在正常受试者体内的药代动力学。
Clin Pharmacol Ther. 1976 Oct;20(4):401-12. doi: 10.1002/cpt1976204401.
10
Simplified method for the determination of oxprenolol and other beta-receptor-blocking agents in biological fluids by gas-liquid chromatography.
J Chromatogr. 1976 Jun 9;121(1):72-5. doi: 10.1016/s0021-9673(00)82299-2.
Zotero 插件