传统型和缓释型氧烯洛尔在空腹和非空腹个体中的生物利用度。
Bioavailability of conventional and slow-release oxprenolol in fasted and nonfasted individuals.
作者信息
Dawes C P, Kendall M J, Welling P G
出版信息
Br J Clin Pharmacol. 1979 Mar;7(3):299-302. doi: 10.1111/j.1365-2125.1979.tb00936.x.
Abstract
1 The influence of food and plasma levels of oxprenolol was examined in healthy female volunteers using both conventional and slow-release formulations. 2 There were no significant trends in plasma drug profiles due to food with either formulation. Elimination half-lives were longer after food with conventional tablets, presumably due to continued absorption. The opposite effect was seen with slow-release tablets. 3 Slow-release oxprenolol is, under the conditions of this study, a reliable and convenient dosage form, providing similar plasma-drug profiles in fasted and nonfasted individuals.
摘要
1 在健康女性志愿者中，使用常规制剂和缓释制剂研究了食物和氧烯洛尔血浆水平的影响。2 两种制剂在进食后血浆药物曲线均无显著变化趋势。常规片剂进食后消除半衰期延长，可能是由于持续吸收。而缓释片剂则出现相反的效果。3 在本研究条件下，缓释氧烯洛尔是一种可靠且方便的剂型，在禁食和非禁食个体中提供相似的血浆药物曲线。
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