来自硫酸软骨素4、硫酸皮肤素和硫酸乙酰肝素的X射线衍射图谱。

X-ray-diffraction patterns from chondroitin 4-sulphate, dermatan sulphate and heparan sulphate.

作者信息

Atkins E D, Laurent T C

出版信息

Biochem J. 1973 Jul;133(3):605-6. doi: 10.1042/bj1330605.

DOI:10.1042/bj1330605

PMID:4270110

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1177740/

Abstract

Ordered conformations from the sodium salts of chondroitin 4-sulphate, dermatan sulphate and heparan sulphate were observed by X-ray diffraction. Chondroitin 4-sulphate shows similar threefold helical character to that previously reported for chondroitin 6-sulphate and hyaluronates. Dermatan sulphate forms an eightfold helix with an axial rise per disaccharide of 0.93nm, which favours the l-iduronic acid moiety in the normal C1 chair form. The layer-line spacing and axial projection in heparan sulphate of 1.86nm favours a tetrasaccharide repeat with glycosidic linkages alternating beta-d-(1-->4) and alpha-d-(1-->4).

摘要

通过X射线衍射观察到了硫酸软骨素4钠盐、硫酸皮肤素和硫酸乙酰肝素的有序构象。硫酸软骨素4显示出与先前报道的硫酸软骨素6和透明质酸盐相似的三重螺旋特征。硫酸皮肤素形成八重螺旋，每个二糖的轴向上升为0.93nm，这有利于正常C1椅式构象中的L-艾杜糖醛酸部分。硫酸乙酰肝素中1.86nm的层线间距和轴向投影有利于具有交替的β-d-(1→4)和α-d-(1→4)糖苷键的四糖重复序列。