Jacyk W K, Damisah M
Br J Dermatol. 1979 Feb;100(2):131-5. doi: 10.1111/j.1365-2133.1979.tb05550.x.
Results of a detailed clinical and laboratory study of 37 Nigerian patients with chronic discoid lupus erythematosus are presented. Patients with chronic discoid lupus erythematosus constituted 0.46% of all out-patients seen in the skin clinic between May 1974 and December 1977. A preponderance of females was noticed (female/male ratio of 5:1), while the age distribution of African patients corresponded to values characteristic for the condition seen in other geographical regions. Several morphological types of the condition have been seen. The vitiligoid variant of chronic discoid lupus erythematosus seems to be common in West Africans. Sixteen out of 37 patients presented laboratory abnormalities considered as markers of the association between chronic and systemic lupus erythematosus. Their significance, however is, uncertain as it has been demonstrated on several occasions that in a tropical milieu heavy parasitic infections produce marked immunological disturbances. The problem of the relationship between chronic and systemic lupus erythematosus is discussed and the literature on the incidence of chronic discoid lupus erythematosus in various African countries is reviewed.
本文介绍了对37例尼日利亚慢性盘状红斑狼疮患者进行详细临床和实验室研究的结果。在1974年5月至1977年12月期间，慢性盘状红斑狼疮患者占皮肤科门诊所有患者的0.46%。观察到女性占多数（女性/男性比例为5:1），而非洲患者的年龄分布与其他地理区域所见该病的特征值相符。已观察到该病的几种形态学类型。慢性盘状红斑狼疮的白癜风样变体在西非似乎很常见。37例患者中有16例出现被视为慢性和系统性红斑狼疮关联标志的实验室异常。然而，其意义尚不确定，因为多次证明在热带环境中严重的寄生虫感染会产生明显的免疫紊乱。文中讨论了慢性和系统性红斑狼疮之间的关系问题，并综述了关于非洲各国慢性盘状红斑狼疮发病率的文献。
