增殖性镰状视网膜病变的冷冻疗法，II：三次冻融循环

Goldbaum M H, Fletcher R C, Jampol L M, Goldberg M F

Br J Ophthalmol. 1979 Feb;63(2):97-101. doi: 10.1136/bjo.63.2.97.

Complete closure of retinal neovascularisation due to proliferative sickle cell retinopathy was achieved in 28 'sea fans' (areas of neovascularisation) in 9 eyes of 9 patients by means of a triple freeze-thaw technique. However, 2 eyes developed subsequent rhegmatogenous retinal detachments, presumably related to vitreous traction on necrotic retina. We therefore recommend photocoagulation as the best treatment of proliferative sickle cell retinopathy. If opacities in the media prevent photocoagulation, a single freeze-thaw cycle is preferable.

采用三次冻融技术，9例患者9只眼中的28个“海扇”（新生血管区域）实现了增殖性镰状细胞视网膜病变所致视网膜新生血管的完全闭合。然而，2只眼随后发生了孔源性视网膜脱离，推测与坏死视网膜上的玻璃体牵拉有关。因此，我们建议光凝术作为增殖性镰状细胞视网膜病变的最佳治疗方法。如果介质混浊妨碍光凝术，则单次冻融周期更为可取。