Paylor R R, Carney M D, Ogura Y, Cunha-Vaz J G, Jampol L M, Goldberg M F
Int Ophthalmol. 1986 May;9(2-3):103-8. doi: 10.1007/BF00159838.
Nineteen eyes with background sickle cell retinopathy, eleven from patients with SC disease, eight from patients with SS disease, and twelve eyes with proliferative sickle cell retinopathy were examined by direct and indirect ophthalmoscopy, slit-lamp, fluorescein angiography and vitreous fluorophotometry. Calculation of the alteration of the blood-retinal barrier (BRB) and estimation of the diffusion coefficients of fluorescein in the vitreous were performed by fluorophotometry. In background sickle cell retinopathy, the results show a normally functioning BRB in the posterior pole. Abnormally increased fluorescence values to the mid-vitreous (peripheral leakage) were found only in 3 of these 19 eyes, at the two-hour examination (all SC patients). Similarly, mid-vitreous fluorescence values at the two-hour examination were 4.19 +/- 1.52 ng/ml in eyes of patients with SC disease, compared with 2.65 +/- 0.56 ng/ml in eyes of patients with SS disease. All eyes with background sickle cell retinopathy, except one, showed values for the coefficient of diffusion of fluorescein within normal limits, indicating normal vitreous gel structure. In proliferative retinopathy, the mid-vitreous fluorophotometry readings were abnormally increased, correlating well with the extent of the peripheral angiographic changes (neovascularization). The coefficient of diffusion of fluorescein in the vitreous was generally increased in the eyes with proliferative retinopathy (15.0 +/- 8.4 X 10(-4) cm2/min) in comparison with a mean value of 5.4 +/- 1.4 X 10(-4) cm2/min in the eyes with background sickle cell retinopathy, suggesting an alteration of the vitreous structure eyes with proliferative retinopathy. Fluorophotometry is considered a useful tool to follow patients with sickle cell retinopathy by quantitating peripheral retinal vascular leakage.
对19只患有镰状细胞性视网膜病变（背景型）的眼睛进行了检查，其中11只来自患SC病的患者，8只来自患SS病的患者，另外还对12只患有增殖性镰状细胞性视网膜病变的眼睛进行了直接和间接检眼镜检查、裂隙灯检查、荧光素血管造影和玻璃体荧光光度测定。通过荧光光度测定法计算血视网膜屏障（BRB）的改变，并估计荧光素在玻璃体中的扩散系数。在背景型镰状细胞性视网膜病变中，结果显示后极部的BRB功能正常。仅在这19只眼睛中的3只（均为SC病患者）在两小时检查时发现玻璃体中部荧光值异常升高（周边渗漏）。同样，SC病患者眼睛在两小时检查时的玻璃体中部荧光值为4.19±1.52 ng/ml，而SS病患者眼睛为2.65±0.56 ng/ml。除一只眼睛外，所有患有背景型镰状细胞性视网膜病变的眼睛荧光素扩散系数值均在正常范围内，表明玻璃体凝胶结构正常。在增殖性视网膜病变中，玻璃体中部荧光光度测定读数异常升高，与周边血管造影变化（新生血管形成）程度密切相关。与背景型镰状细胞性视网膜病变眼睛的平均值5.4±1.4×10⁻⁴ cm²/min相比，增殖性视网膜病变眼睛中荧光素在玻璃体中的扩散系数普遍升高（15.0±8.4×10⁻⁴ cm²/min），提示增殖性视网膜病变眼睛的玻璃体结构发生改变。荧光光度测定法被认为是通过定量周边视网膜血管渗漏来跟踪镰状细胞性视网膜病变患者的有用工具。
