Penttinen K, Wager O, Räsänen J A, Myllylä G, Haapanen E
Clin Exp Immunol. 1973 Nov;15(3):409-16.
Hepatitis and other sera were studied for direct platelet aggregating (P1.A.) activity in non-heated and heat-treated state, for inhibitability of P1.A. by antiglobulin active cryoglobulin IgM components (Cryo-IgM), and for sedimentation velocity of P1.A. activity by sucrose gradient centrifugation. Three distinct patterns of direct P1.A. activity were established: (1) aggregated IgG type': heating-dependent, [unk]19S, inhibitable by Cryo-IgM, serum anticomplementary; (2) antibody type': heating-independent, 7S and/or 19S, non-inhibitable by Cryo-IgM, serum not anticomplementary; and (3) `immune-complex type': heating-independent, [unk]19S, inhibitable by Cryo-IgM, anticomplementary activity present or absent. In the heavy P1.A.-active sucrose gradient serum fractions of one patient, only IgG4 Gm markers were detected.
对肝炎血清及其他血清在未加热和热处理状态下的直接血小板聚集（P1.A.）活性、抗球蛋白活性冷球蛋白IgM成分（Cryo-IgM）对P1.A.的抑制能力以及通过蔗糖梯度离心法测定P1.A.活性的沉降速度进行了研究。确定了三种不同的直接P1.A.活性模式：（1）“聚集IgG型”：依赖加热，[未知]19S，可被Cryo-IgM抑制，血清具有抗补体活性；（2）“抗体型”：不依赖加热，7S和/或19S，不能被Cryo-IgM抑制，血清无抗补体活性；（3）“免疫复合物型”：不依赖加热，[未知]19S，可被Cryo-IgM抑制，存在或不存在抗补体活性。在一名患者的重P1.A.活性蔗糖梯度血清组分中，仅检测到IgG4 Gm标记物。
