Dupont B, Ballow M, Hansen J A, Quick C, Yunis E J, Good R A
Proc Natl Acad Sci U S A. 1974 Mar;71(3):867-71. doi: 10.1073/pnas.71.3.867.
We have studied the effect of dialyzable transfer factor therapy on three patients with immunodeficiency disease and in one patient who demonstrated no evidence of deficiency of either humoral or cellular immunity. We found evidence for nonspecificity in the effect of transfer factor on mixed lymphocyte culture reactivity. The data suggest that in patients with immunodeficiency disease a maturation of lymphocytes may lead to a generalized increased immune responsiveness. More profoundly, our data show that transfer factor may induce changes in the expression of histocompatibility determinants. We observed changes in the expression of determinants capable of stimulating in the mixed lymphocyte culture reaction as well as an increase in the capacity of lymphocytes to respond.
我们研究了可透析转移因子疗法对三名免疫缺陷疾病患者以及一名未显示体液免疫或细胞免疫缺陷证据的患者的影响。我们发现转移因子对混合淋巴细胞培养反应性的影响存在非特异性证据。数据表明，在免疫缺陷疾病患者中，淋巴细胞的成熟可能导致全身免疫反应性普遍增强。更重要的是，我们的数据表明转移因子可能诱导组织相容性决定簇表达的变化。我们观察到能够在混合淋巴细胞培养反应中刺激的决定簇表达发生变化，以及淋巴细胞反应能力的增强。
