Turscott R G, Lopez-Alvarez J, Pettit J R
Can J Comp Med. 1974 Apr;38(2):160-7.
The pathogenesis of infection with Escherichia coli was studied in chickens using live O78:K80 cells and a heat-labile chick lethal toxin. The results obtained were compared with those observed in field outbreaks. The common histological findings of subepicardial edema and congestion, focal necrosis in the spleen and focal necrosis, congestion, edema and accumulation of fibrin in the liver support an active role for chick lethal toxin in the pathogenesis of E. coli disease.
利用活的O78:K80大肠杆菌细胞和一种不耐热的雏鸡致死毒素,对鸡感染大肠杆菌的发病机制进行了研究。将所得结果与在野外疫情中观察到的结果进行了比较。心外膜下水肿和充血、脾脏局灶性坏死以及肝脏局灶性坏死、充血、水肿和纤维蛋白积聚等常见组织学表现,支持雏鸡致死毒素在大肠杆菌病发病机制中起积极作用。