Seneviratne K N, Weerasuriya A
J Neurol Neurosurg Psychiatry. 1974 May;37(5):502-13. doi: 10.1136/jnnp.37.5.502.
Anoxia and KC1 have been used to inactivate peripheral nerves by depolarization conduction block. Investigation of the inactivation patterns in isolated sciatic nerves of healthy and alloxan-diabetic rats suggests that the paranodal gap substance of healthy nerve behaves as an effective periaxonal diffusion barrier. In diabetic nerve the permeability of this barrier is significantly increased. A marked reduction in the K' binding capacity of the nodal gap substance has been demonstrated in myelinated nerves of human diabetics and alloxan diabetic rats.
缺氧和氯化钾已被用于通过去极化传导阻滞使外周神经失活。对健康大鼠和四氧嘧啶糖尿病大鼠离体坐骨神经失活模式的研究表明，健康神经的结旁间隙物质起着有效的轴突周扩散屏障的作用。在糖尿病神经中，这种屏障的通透性显著增加。在人类糖尿病患者和四氧嘧啶糖尿病大鼠的有髓神经中，已证实结间隙物质的钾离子结合能力明显降低。
