高钾血症对周围神经兴奋性的影响。
Effects of hyperkalaemia on the excitability of peripheral nerve.
作者信息
Seneviratne K N, Peiris O A, Weerasuriya A
出版信息
J Neurol Neurosurg Psychiatry. 1972 Apr;35(2):149-55. doi: 10.1136/jnnp.35.2.149.
Abstract
An experimental animal model has been developed for the study of excitability change in peripheral nerve during limb ischaemia. This model has been used to investigate the effects of hyperkalaemia on the sequence of excitability change that occurs during cuff-induced limb ischaemia and in the post-ischaemic recovery period. The results lend support to the hypothesis that the dynamics of K ion concentration in the periaxonal space play a critical role in determining these excitability changes and that the polyanionic mucopolysaccharide gap substance of the node of Ranvier is likely to constitute the diffusion barrier that defines the periaxonal space.
摘要
已建立一种实验动物模型，用于研究肢体缺血期间外周神经兴奋性的变化。该模型已被用于研究高钾血症对袖带诱导的肢体缺血期间及缺血后恢复期发生的兴奋性变化序列的影响。这些结果支持了以下假设：轴突周隙中钾离子浓度的动态变化在决定这些兴奋性变化中起关键作用，并且郎飞结的聚阴离子粘多糖间隙物质可能构成了界定轴突周隙的扩散屏障。
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