Givan K F, Keyl A
Can Med Assoc J. 1974 Jul 6;111(1):44-6.
The antibiotic sensitivity pattern of 3872 isolates of N. gonorrhoeae tested in Toronto from 1969 to 1973 is reviewed. An increase in resistance to both penicillin and tetracycline was noted up to 1971, but no further increase has occurred since then. Ninety-seven percent of 135 patients with "sensitive" strains (inhibited by 0.3 U/ml of penicillin and/or 0.5 mug/ml of tetracycline) were cured by either 8 g of tetracycline or 5,000,000 U of penicillin, whereas only 59% of 58 patients with "resistant" strains (requiring 1.0 U/ml of penicillin and/or 2.0 mug/ml of tetracycline for inhibition) were cured by the same dosage. Spectinomycin appears to be an acceptable alternative therapy. Maximum doses of the chosen drug are recommended in the hope of retarding further spread of more resistant organisms.
本文回顾了1969年至1973年在多伦多检测的3872株淋病奈瑟菌的抗生素敏感性模式。到1971年，对青霉素和四环素的耐药性均有所增加，但此后未再进一步增加。135例感染“敏感”菌株（被0.3 U/ml青霉素和/或0.5μg/ml四环素抑制）的患者中，97%通过8 g四环素或500万U青霉素治愈，而58例感染“耐药”菌株（抑制需1.0 U/ml青霉素和/或2.0μg/ml四环素）的患者中，只有59%通过相同剂量治愈。壮观霉素似乎是一种可接受的替代疗法。建议使用所选药物的最大剂量，以期延缓更耐药菌株的进一步传播。
