Doig P A, Ruhnke H L, MacKay A L, Palmer N C
Can Vet J. 1979 Apr;20(4):89-94.
A granular vulvitis syndrome associated with ureaplasma infection was first recognized in Ontario dairy herds in 1972. The acute form of the disease was characterized by a purulent vulvar discharge, an inflamed hyperemic vulvar mucosa and varying degrees of granularity. In the chronic form, there was an absence of a purulent discharge and a gradual decline in the severity of the hyperemia and granularity. Epithelial inclusion cysts were observed in the vulvar epithelium of approximately 10% of affected cows.A seasonal variation in the incidence of the disease was observed. Herd morbidities during the summer months reached a low of 37% and increased to 75% during the winter months with constant housing.When widespread in herds, the acute form of the disease had a significant effect on fertility. In four herds examined, first service conceptions dropped on average by 27%. The chronic form of the disease had a less detrimental effect on fertility with first service conceptions being reduced on average by 13%. Intrauterine infusions of a tetracycline 24 hours postbreeding were found to be of value in improving conception rates in acutely affected herds.
1972年，在安大略省的奶牛群中首次发现了一种与脲原体感染相关的颗粒性外阴炎综合征。该疾病的急性形式表现为脓性外阴分泌物、外阴黏膜充血发炎以及不同程度的颗粒状。慢性形式则表现为无脓性分泌物，充血和颗粒状的严重程度逐渐下降。在约10%的患病奶牛的外阴上皮中观察到上皮包涵体囊肿。观察到该疾病的发病率存在季节性变化。夏季牛群发病率低至37%，冬季持续圈养时升至75%。当该病在牛群中广泛传播时，急性形式对繁殖力有显著影响。在检查的四个牛群中，首次配种受孕率平均下降了27%。慢性形式对繁殖力的不利影响较小，首次配种受孕率平均降低13%。发现在配种后24小时进行宫内四环素灌注对提高急性感染牛群的受孕率有价值。
